Author | Rosário, Mateus Santana do | |
Author | Jesus, Pedro Antônio Pereira de | |
Author | Farias, Daniel Santana | |
Author | Novaes, Marco Antônio Caires | |
Author | Francisco, Marcos Vinicius Lima Oliveira | |
Author | Santos, Cleiton Silva | |
Author | Moura, Daniel | |
Author | Lima, Fernanda Washington de M. | |
Author | Alcantara, Luiz Carlos Junior | |
Author | Siqueira, Isadora Cristina de | |
Access date | 2023-03-08T16:36:19Z | |
Available date | 2023-03-08T16:36:19Z | |
Document date | 2022 | |
Citation | ROSÁRIO, Mateus Santana do et al. Guillain-Barré syndrome and Miller Fisher Syndrome in association with an arboviral outbreak: a Brazilian case series. Frontiers in Medicine, v. 9, p. 1-7, 2022. | en_US |
ISSN | 2296-858X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57282 | |
Sponsorship | Ministério da Ciência, Tecnologia, Inovação (MCTI).
Financiadora de Estudos e Projetos (FINEP).
Fundo Nacional para o Desenvolvimento da Ciência e Tecnologia (FNDCT).
Programa de Excelência em Pesquisa (PROEP).
Instituto Gonçalo Moniz (IGM-Fiocruz) | en_US |
Language | eng | en_US |
Publisher | Frontiers Media | en_US |
Rights | open access | en_US |
Subject in Portuguese | Síndrome de Guillain-Barré | en_US |
Subject in Portuguese | Síndrome de Miller Fisher | en_US |
Subject in Portuguese | Zika vírus | en_US |
Subject in Portuguese | Dengue | en_US |
Subject in Portuguese | Chikungunya | en_US |
Title | Guillain-Barré syndrome and Miller Fisher syndrome in association with an arboviral outbreak: a Brazilian case seriesw | en_US |
Type | Article | en_US |
DOI | 10.3389/fmed.2022.911175 | |
Abstract | Introduction: Guillain-Barré syndrome (GBS) in association with arboviruses, such as Zika, chikungunya, and dengue, has been previously documented; however, Miller-Fisher Syndrome (MFS) and other GBS subtypes are rarely reported. Methods: We identified a series of GBS and MFS cases that were followed during the Zika virus outbreak in Salvador, Brazil (2015-2016). Blood and CSF samples were collected for virus diagnosis. In addition, serological studies to verify previous arboviral infection and electromyography (EMG) were performed. Results: Of the 14 patients enrolled, 10 were diagnosed with GBS, including three GBS subtypes (two cases of bifacial weakness with paresthesia and one case of paraparetic GBS), and four as MFS. IgM antibodies against one or more of three arboviruses were present in 11 (78.6%) patients: anti-zika IgM positivity in eight (57%), anti-Chikungunya IgM in three (21%), and anti-Dengue in one (7%) individual. A single case was positive for both anti-Dengue IgM and anti-Chikungunya IgM, suggesting co-infection. EMG revealed an AIDP pattern in all nine patients analyzed. Conclusion: The current case series contributes to our knowledge on the clinical presentation of arbovirus-associated GBS and its subtypes, including MFS, and serves as an alert to clinicians and other healthcare professionals in regions affected by arbovirus outbreaks. We highlight the importance of recognizing arboviruses in diagnosing GBS and its subtypes. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil / Santa Casa de Misericórdia da Bahia. Hospital Santa Izabel. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Secretaria Estadual da Saúde da Bahia. Hospital Geral Roberto Santos. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Monte Tabor. Hospital São Rafael, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Imunologia das Doenças Infecciosas., Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Imunologia das Doenças Infecciosas., Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivirus. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Subject | Guillain-Barré syndrome | en_US |
Subject | Miller Fisher syndrome | en_US |
Subject | Zika virus | en_US |
Subject | Dengue | en_US |
Subject | Chikungunya | en_US |
DeCS | Síndrome de Guillain-Barré | en_US |
DeCS | Síndrome de Miller Fisher | en_US |
DeCS | Zika virus | en_US |
DeCS | Dengue | en_US |
DeCS | Vírus Chikungunya | en_US |