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ArtículoDerechos de autor
Acceso abierto
Fecha del embargo
2023
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- INI - Artigos de Periódicos [3397]
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MENINGEAL SPOROTRICHOSIS DUE TO SPOROTHRIX BRASILIENSIS: A 21-YEAR COHORT STUDY FROM A BRAZILIAN REFERENCE CENTER
Esporotricose
Meningite
HIV
Síndrome inflamatória da reconstituição imunológica
Sporotrichosis
Meningitis
HIV
Immune reconstitution inflammatory syndrome
Autor
Lima, Marco A.
Freitas, Dayvison F. S.
Oliveira, Raquel V. C.
Fichman, Vivian
Varon, Andréa G.
Freitas, Andréa D.
Lamas, Cristiane C.
Andrade, Hugo B.
Veloso, Valdiléa G.
Almeida-Paes, Rodrigo
Almeida-Silva, Fernando
Zancopé-Oliveira, Rosely Maria
Macedo, Priscila M. de
Valle, Antonio C. F.
Silva, Marcus T. T.
Araújo, Abelardo Q. C.
Gutierrez-Galhardo, Maria
Freitas, Dayvison F. S.
Oliveira, Raquel V. C.
Fichman, Vivian
Varon, Andréa G.
Freitas, Andréa D.
Lamas, Cristiane C.
Andrade, Hugo B.
Veloso, Valdiléa G.
Almeida-Paes, Rodrigo
Almeida-Silva, Fernando
Zancopé-Oliveira, Rosely Maria
Macedo, Priscila M. de
Valle, Antonio C. F.
Silva, Marcus T. T.
Araújo, Abelardo Q. C.
Gutierrez-Galhardo, Maria
Afiliación
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Neurology Section. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Deolindo Couto Institute of Neurology. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Deolindo Couto Institute of Neurology. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
Meningeal sporotrichosis is rare and occurs predominantly in immunosuppressed indi viduals. This retrospective study explored clinical and laboratory characteristics, treatment, and prognosis of patients with disseminated sporotrichosis who underwent lumbar puncture (LP) at a Brazilian reference center from 1999 to 2020. Kaplan–Meier and Cox regression models were used to estimate overall survival and hazard ratios. Among 57 enrolled patients, 17 had meningitis. Fifteen (88.2%) had HIV infection, and in 6 of them, neurological manifestations occurred because of the immune reconstitution inflammatory syndrome (IRIS). The most frequent symptom was headache (88.2%). Meningeal symptoms at first LP were absent in 7/17 (41.2%) patients. Sporothrix was diagnosed in cerebrospinal fluid either by culture or by polymerase chain reaction in seven and four patients, respectively. All but one patient received prolonged courses of amphotericin B formulations, and seven received posaconazole, but relapses were frequent. Lethality among patients with meningitis was 64.7%, with a higher chance of death compared to those without meningitis (HR = 3.87; IC95% = 1.23;12.17). Meningeal sporotrichosis occurs mostly in people with HIV and can be associated with IRIS. Screening LP is indicated in patients with disseminated disease despite the absence of neurological complaints. Meningitis is associated with poor prognosis, and better treatment strategies are needed.
Palabras clave en portugues
Sporothrix brasiliensisEsporotricose
Meningite
HIV
Síndrome inflamatória da reconstituição imunológica
Palabras clave en ingles
Sporothrix brasiliensisSporotrichosis
Meningitis
HIV
Immune reconstitution inflammatory syndrome
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