Author | Lelis, Deborah de Farias | |
Author | Cunha, Roberto S. | |
Author | Santos, Raul D. | |
Author | Sposito, Andrei C. | |
Author | Griep, Rosane Härter | |
Author | Barreto, Sandhi Maria | |
Author | Molina, Maria del Carmen B. | |
Author | Schmidt, Maria Inês | |
Author | Duncan, Bruce B. | |
Author | Bensenor, Isabela | |
Author | Lotufo, Paulo Andrade | |
Author | Mill, José Geraldo | |
Author | Baldo, Marcelo Perim | |
Access date | 2023-03-17T18:00:27Z | |
Available date | 2023-03-17T18:00:27Z | |
Document date | 2022 | |
Citation | LELIS, Deborah de Farias et al. Association Between Triglycerides, High-Density Lipoprotein Cholesterol, and Their Ratio With the Pulse Wave Velocity in Adults From the ELSA-Brasil Study. Angiology, v.0(0), p. 1-10, 2022. | en_US |
ISSN | 1940-1574 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57425 | |
Language | eng | en_US |
Publisher | SAGE | en_US |
Rights | open access | |
Subject in Portuguese | Rigidez arterial | en_US |
Subject in Portuguese | Triglicerídeos | en_US |
Subject in Portuguese | Colesterol de lipoproteína de alta densidade | en_US |
Subject in Portuguese | Triglicerídeos/alta densidade | en_US |
Subject in Portuguese | Taxa de colesterol de lipoproteína | en_US |
Title | Association Between Triglycerides, High-Density Lipoprotein Cholesterol, and Their Ratio With the Pulse Wave Velocity in Adults From the ELSA-Brasil Study | en_US |
Type | Article | |
DOI | 10.1177/00033197221121434 | |
Abstract | Atherogenic dyslipidemia is a risk factor for cardiovascular diseases. The present study aimed to evaluate the association
between triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and the triglycerides to high-density lipoprotein
(TG/HDL-C) ratio with carotid-femoral pulse wave velocity (cf-PWV), a marker of vascular stiffness. Anthropometric,
biochemical, and clinical data from 13,732 adults were used to assess this association. Individuals within the third TG/HDL-C
tertile presented worse anthropometric, biochemical, and clinical profiles as compared with the participants in the lower TG/
HDL-C tertile. There was a linear association between TG, HDL-C, and TG/HDL-C ratio and cf-PWV in both men and women
(stronger in women). After adjustment for confounders, lower levels of HDL-C were associated with increased cf-PWV in men
(9.63 ± .02 m/s) and women (8.90 ± .03 m/s). However, TG was not significantly associated with cf-PWV after adjustment,
regardless of sex. An increased TG/HDL-C ratio is associated with higher cf-PWV only in women (9.01 ± .03 m/s), but after
adjustment for HDL-C levels, the association was non-significant (8.99 ± .03 m/s). These results highlight the stronger association
of HDL-C with arterial stiffness, and that the association of TG/HDL-C with cf-PWV is dependent on HDL-C. | en_US |
Affilliation | Universidade Estadual de Montes Claros. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | en_US |
Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. INCOR -Instituto do Coração. Clínica Lipídica. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Divisão de Cardiologia. São Paulo, SP. Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal de Minas Gerais, Faculdade de Medicina. Belo Horizonte, MG, Brasil. | en_US |
Affilliation | Universidade Federal do Espírito Santo. Programa de Pós-Graduação em Saúde Pública. Vitória, ES, Brasil. | en_US |
Affilliation | Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Escola de Medicina. Porto Alegre, RS, Brasil. | en_US |
Affilliation | Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Escola de Medicina. Porto Alegre, RS, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade de São Paulo. Centro de Pesquisa Clínica e Epidemiológica. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidade Federal do Espírito Santo. Departamento de Ciências Fisiológicas. Vitória, ES, Brasil. | en_US |
Affilliation | Universidade Estadual de Montes Claros. Departamento de Fisiopatologia. Montes Claros, MG, Brasil. | en_US |
Subject | Arterial stiffness | en_US |
Subject | Triglycerides | en_US |
Subject | High-density lipoprotein cholesterol | en_US |
Subject | Triglycerides/high-density | en_US |
Subject | Lipoprotein cholesterol ratio | en_US |
Embargo date | 2028 | |