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Autor | Coelho, Lara E. | |
Autor | Torres, Thiago S. | |
Autor | Jalil, Emilia M. | |
Autor | Cardoso, Sandra W. | |
Autor | Moreira, Ronaldo I. | |
Autor | Calvet, Guilherme A. | |
Autor | Pacheco, Antônio G. | |
Autor | Veloso, Valdiléa G. | |
Autor | Grinsztejn, Beatriz | |
Autor | Luz, Paula M. | |
Fecha de acceso | 2023-04-24T22:31:12Z | |
Fecha de disponibilización | 2023-04-24T22:31:12Z | |
Fecha de publicación | 2023 | |
Referencia | COELHO, Lara E. et al. Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases, v. 27, n. 2, p. 1-11, Mar./Apr. 2023. | en_US |
ISSN | 1413-8670 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/57955 | |
Promoción | This work was supported in part by NIH-funded Caribbean, Central and South America network for HIV epidemiology (CCASAnet), a member cohort of the International Epidemiologic Databases to Evaluate AIDS (leDEA) (U01AI069923) and Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz. AGP, BG, PML, TST acknowledge funding from Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq) and Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ). | en_US |
Idioma | eng | en_US |
Editor | Sociedade Brasileira de Infectologia | en_US |
Derechos de autor | open access | en_US |
Título | Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil | en_US |
Tipo del documento | Article | en_US |
DOI | 10.1016/j.bjid.2023.102740 | |
Resumen en Inglés | Background: Antiretroviral therapy use has led to a decline in HIV-related mortality yet disparities by gender and/or sexual orientation may exist. In this study, we estimated hazards of death in people living with HIV (PLWH) according to gender and sexual orientation. Methods: We included PLWH ≥ 18 years enrolled between 2000 and 2018 at INI/Fiocruz, Rio de Janeiro, Brazil. Participants were grouped as cisgender or transgender women, cisgender men who have sex with men (MSM) or men who have sex with women, or cisgender men with unknown sexual orientation. We assessed disparities in the hazard of death using Cox proportional hazards models. Results: Among 5,576 PLWH, median age at enrollment was 35 years, 39% were MSM, 28% cisgender women, 23% men who have sex with women, 5% transgender women, and 5% men with unknown sexual orientation. A total of 795 deaths occurred in 39,141 person-years of follow-up. Mortality rates per 1,000 person-years were: 82.4 for men with unknown sexual orientation, 24.5 for men who have sex with women, 18.3 for cisgender, 16.6 for transgender women, and 15.1 for MSM. Compared to MSM, men with unknown sexual orientation had the highest death hazard ratio (adjusted hazard ratio [aHR] 2.93, 95% confidence interval [CI] 2.35-3.81), followed by men who have sex with women (aHR 1.17, 95%CI 0.96, 1.43); death hazard ratios for cisgender and transgender women were not statistically different. Conclusion: We observed disparities in the hazard of death for men with unknown sexual orientation and men who have sex with women despite universal access to antiretroviral therapy in Brazil. Future work should characterize and assist men with unknown sexual orientation with tailored policies and interventions. Increased hazard of death was not observed for transgender women, which probably results from interventions implemented in our service to reach, engage, retain, and support this population. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil. | en_US |
Palavras clave en Inglês | Disclosure | en_US |
Palavras clave en Inglês | Gender | en_US |
Palavras clave en Inglês | HIV/AIDS | en_US |
Palavras clave en Inglês | Mortality | en_US |
Palavras clave en Inglês | Sexual orientation | en_US |
Palavras clave en Inglês | Survival | en_US |
e-ISSN | 1678-4391 |