Author | Silva, Luciano Kalabric | |
Author | Blanton, Ronald Edward | |
Author | Parrado, Antonio R | |
Author | Melo, Paulo S | |
Author | Morato, Vanessa G | |
Author | Reis, Eliana Almeida Gomes | |
Author | Dias, Juarez Pereira | |
Author | Castro, Jesuina M | |
Author | Vasconcelos, Pedro F. C | |
Author | Goddard, Katrina A. B | |
Author | Barreto, Maurício Lima | |
Author | Reis, Mitermayer Galvão dos | |
Author | Teixeira, Glória | |
Access date | 2012-11-14T22:30:39Z | |
Available date | 2012-11-14T22:30:39Z | |
Document date | 2010 | |
Citation | SILVA, L. K. et al. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. European Journal of Human Genetics, v. 18, n. 11, p. 12221-1227, nov. 2010. | pt_BR |
ISSN | 1476-5438 | |
URI | https://www.arca.fiocruz.br/handle/icict/5816 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Dengue hemorrhagic fever is associated with polymorphisms in JAK1 | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/ejhg.2010.98 | |
Abstract | To identify genes associated with the clinical presentation of dengue, 50 cases of probable or possible dengue hemorrhagic fever (DHF), 236 dengue fever (DF), and 236 asymptomatic infections were genotyped for 593 single-nucleotide polymorphisms (SNPs) in 56 genes across the type 1 interferon (IFN) response pathway as well as other important candidate genes. By single locus analysis comparing DHF with DF, 11 of the 51 markers with P<0.05 were in the JAK1 gene. Five markers were significantly associated by false discovery rate criteria (q<0.20 when P<6 × 10(-4)). The JAK1 SNPs showed differential distribution by ethnicity and ancestry consistent with epidemiologic observations in the Americas. The association remained significant after controlling for ancestry and income. No association was observed with markers in the gene encoding CD209 (DC-SIGN). An association between DHF and JAK1 polymorphisms is in agreement with expression profiles showing generalized decreased type 1 IFN-stimulated gene expression in these patients. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Case University. Center for Global Health and Disease. Cleveland, OH, United State of America | pt_BR |
Affilliation | Case University. Division of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Cleveland, OH, United States of America | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Secretaria de Saúde do Estado da Bahia. Diretoria de Vigilância Epidemiológica. Salvador, BA, Brasil | pt_BR |
Affilliation | Secretaria de Saúde do Estado da Bahia. Diretoria de Vigilância Epidemiológica. Salvador, BA, Brasil | pt_BR |
Affilliation | Instituto Evandro Chagas. Belém, PA, Brasil | pt_BR |
Affilliation | Case University. Division of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Cleveland, OH, United States of America | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil | pt_BR |
Subject | Flavivirus | pt_BR |
Subject | Population structure | pt_BR |
Subject | Interferon | pt_BR |
Subject | Genetic association | pt_BR |
Subject | Brazil | pt_BR |
DeCS | Febre Hemorágica da Dengue/genética | pt_BR |
DeCS | Predisposição Genética para Doença/genética | pt_BR |
DeCS | Janus Quinase 1/genética | pt_BR |
DeCS | Polimorfismo de Nucleotídeo Único | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |