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IN VITRO TRYPANOCIDAL AND ANTIBACTERIAL ACTIVITIES OF ESSENTIAL OILS FROM FOUR SPECIES OF THE FAMILY ANNONACEAE
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Afiliación
Federal Institute of Education Science and Technologyof Rondônia. Porto Velho, RO, Brazil
Federal Institute of Education Science and Technologyof Rondônia. Porto Velho, RO, Brazil
Laboratory of Cellular and Molecular Parasitology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Parasitology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Federal University of Paraná. Departmentof Chemistry. Polytechnic Center. Curitiba, PR, Brazil
Biodiversity Coordinationin Health. Leônidas&Maria Deane Institute. Oswaldo Cruz Foundation. Manaus, AM, Brazil
Biodiversity Coordinationin Health. Leônidas&Maria Deane Institute. Oswaldo Cruz Foundation. Manaus, AM, Brazil
Federal University of MatoGrosso.Institute of Exactand Earth Sciences. Department of Chemistry. Cuiabá, MT, Brazil
Federal Institute of Education Science and Technologyof Rondônia. Porto Velho, RO, Brazil
Laboratory of Cellular and Molecular Parasitology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Laboratory of Cellular and Molecular Parasitology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil
Federal University of Paraná. Departmentof Chemistry. Polytechnic Center. Curitiba, PR, Brazil
Biodiversity Coordinationin Health. Leônidas&Maria Deane Institute. Oswaldo Cruz Foundation. Manaus, AM, Brazil
Biodiversity Coordinationin Health. Leônidas&Maria Deane Institute. Oswaldo Cruz Foundation. Manaus, AM, Brazil
Federal University of MatoGrosso.Institute of Exactand Earth Sciences. Department of Chemistry. Cuiabá, MT, Brazil
Resumen en ingles
The objective of this study was to evaluate the chemical composition, and the trypanocidal and antibacterial activities of the essential oils from four species of Annonaceae: Bocageopsis multiflora (Mart.) R.E.Fr., Duguetia quitarensis Benth., Fusaea longifolia (Aubl.) Saff., and Guatteria punctata (Aubl.) R.A.Howard. The chemical composition of the essential oils from the aerial parts yielded 23, 20, 21 and 23 constituents, respectively, which were identified by GC/MS. The trypanocidal activity was evaluated against the amastigote and trypomastigote forms of T. cruzi. The antibacterial activity was evaluated by the microdilution method against enterohemorrhagic Escherichia coli, Pseudomonas aeruginosa, Streptococcus mutans, Streptococcus pyogenes, and methicillin-resistant Staphylococcus aureus. The results of trypanocidal activity showed that the essential oils of the four species were active at the tested concentrations, with G. punctata essential oil being the most active, with IC50=0.029 mu g/mL, and selectivity index (SI)=32, being 34 times more active than the reference drug benznidazole. All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 4.68-37.5 mu g/mL) against strains of S. mutans.
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