Author | Parise, Barbara K. | |
Author | Santos, Ronaldo B. | |
Author | Mesas, Arthur E. | |
Author | Silva, Wagner A. | |
Author | Giatti, Soraya | |
Author | Aielo, Aline N. | |
Author | Cunha, Lorenna F. | |
Author | Souza, Silvana P. | |
Author | Bortolotto, Luiz A. | |
Author | Griep, Rosane H. | |
Author | Lotufo, Paulo A. | |
Author | Bensenor, Isabela M. | |
Author | Drager, Luciano F. | |
Access date | 2023-05-17T19:33:15Z | |
Available date | 2023-05-17T19:33:15Z | |
Document date | 2023 | |
Citation | PARISE, Barbara K. et al. Sleep irregularity and the association with hypertension and blood pressure levels: the ELSA-Brasil study. Journal of Hypertension, v. 41, n. 4, p. 670-677, Apr. 2023. | en_US |
ISSN | 0263-6352 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58464 | |
Language | eng | en_US |
Publisher | Wolters Kluwer Health, Inc. | en_US |
Rights | restricted access | |
Subject in Portuguese | Ritmos circadianos | en_US |
Subject in Portuguese | Hipertensão | en_US |
Subject in Portuguese | Apneia obstrutiva do sono | en_US |
Subject in Portuguese | Duração do sono | en_US |
Subject in Portuguese | Irregularidade do sono | en_US |
Title | Sleep irregularity and the association with hypertension and blood pressure levels: the ELSA-Brasil study | en_US |
Type | Article | |
DOI | 10.1097/HJH.0000000000003392 | |
Abstract | Methods: Adult participants from the ELSA-Brasil
performed a clinical evaluation including objective sleep
duration (actigraphy), insomnia, and a sleep study for
defining obstructive sleep apnoea (OSA). To quantify sleep
irregularity, we used two parameters obtained through
actigraphy: 7-day standard deviation (SD) of sleep duration
and 7-day SD of sleep-onset timing. A multivariate analysis
was used to determine the independent associations of
sleep irregularity with HTN and SBP/DBP values.
Results: We studied 1720 participants (age 49 8 years;
43.4% men) and 27% fulfilled the HTN diagnosis. After
adjustments for age, gender, race, BMI, excessive alcohol
consumption, physical activity intensity, urinary sodium
excretion, insomnia, objective sleep duration and OSA
(apnoea–hypopnoea index 15 events/h), we found that
the continuous analysis of 7-day SD of sleep duration was
modestly associated with prevalent HTN. However, 7-day
SD of sleep duration more than 90 min was independently
associated with SBP [b: 1.55; 95% confidence interval (CI)
0.23–2.88] and DBP (b: 1.07; 95% CI 0.12–2.01).
Stratification analysis excluding participants with OSA
revealed that a 7-day SD of sleep duration greater than
90 min was associated with a 48% higher chance of
having HTN (OR: 1.48; 95% CI: 1.05–2.07). No significant
associations were observed for the SD of sleep-onset
timing.
Conclusion: Objective measurement of sleep irregularity,
evaluated by SD of sleep duration for 1 week, was
associated with HTN and higher BP levels, especially in
participants without OSA. | en_US |
Affilliation | Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research / Unidade de Hipertensao, Disciplina de Nefrologia. São Paulo, SP, Brasil. | en_US |
Affilliation | Center of Clinical and Epidemiologic Research. Unidade de Hipertensao, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. São Paulo, SP, Brasil. | en_US |
Affilliation | Universidad de Castilla-La Mancha, Spain / Universidade Estandualde Londrina, Postgraduate Program in Public Health, Londrina, PR, Brasil. | en_US |
Affilliation | Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research / Unidade de Hipertensao, Disciplina de Nefrologia. São Paulo, SP, Brasil / Unidade de Hipertensao, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. São Paulo, SP, Brasil. | en_US |
Affilliation | Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research / Unidade de Hipertensao, Disciplina de Nefrologia. São Paulo, SP, Brasil. | en_US |
Affilliation | Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research / Unidade de Hipertensao, Disciplina de Nefrologia. São Paulo, SP, Brasil. | en_US |
Affilliation | Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research / Unidade de Hipertensao, Disciplina de Nefrologia. São Paulo, SP, Brasil / Unidade de Hipertensao, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. São Paulo, SP, Brasil. | en_US |
Affilliation | Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP/ Unidade de Hipertensao, Disciplina de Nefrologia. São Paulo, SP, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Educação em Ambiente e Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research. São Paulo. SP, Brasil. | en_US |
Affilliation | Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research. São Paulo. SP, Brasil. | en_US |
Affilliation | Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Center of Clinical and Epidemiologic Research / Unidade de Hipertensao, Disciplina de Nefrologia. São Paulo, SP, Brasil / Unidade de Hipertensao, Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brasil. | en_US |
Subject | Circadian rhythms | en_US |
Subject | Hypertension | en_US |
Subject | Obstructive sleep apnea | en_US |
Subject | Sleep duration | en_US |
Subject | Sleep irregularity | en_US |
Embargo date | 2030 | |