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2099-12-31
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EFFECTS OF SALIVARY GLAND HOMOGENATE FROM WILD-CAUGHT AND LABORATORY-REARED LUTZOMYIA LONGIPALPIS ON THE EVOLUTION AND IMMUNOMODULATION OF LEISHMANIA (LEISHMANIA) AMAZONENSIS INFECTION
Autor
Afiliación
Laboratory of Pathology of Infectious Diseases. Department of Pathology, Medical School. University of São Paulo. São Paulo, SP, Brazil
Laboratory of Pathology of Infectious Diseases. Department of Pathology, Medical School. University of São Paulo. São Paulo, SP, Brazil
Laboratory of Pathology of Infectious Diseases. Department of Pathology, Medical School. University of São Paulo. São Paulo, SP, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene ́Rachou. Belo Horizonte, MG, Brazil
Laboratory of Pathology of Infectious Diseases. Department of Pathology, Medical School. University of São Paulo. São Paulo, SP, Brazil
Laboratory of Pathology of Infectious Diseases. Department of Pathology, Medical School. University of São Paulo. São Paulo, SP, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Laboratory of Medical Entomology. Fundação Oswaldo Cruz. Centro de Pesquisas Rene ́Rachou. Belo Horizonte, MG, Brazil
Resumen en ingles
We investigated the effects of Lutzomyia longipalpis salivary glands homogenate of wild-caught and laboratory-reared vectors on the lesion evolution and immunomodulation of the infection caused by Leishmania (Leishmania) amazonensis. To compare the effect of both salivary glands homogenate (SGH), C57BL/6 mice were inoculated Subcutaneously into the hind footpads or into the ear dermis with 10(6) promastigotes in the presence or not of SGH from wild-caught and laboratory-colonized sand flies. Comparing SGH groups, the lesion size was lower in mice co-inoculated with wild-caught SGH, as the parasitism and the infiltration of macrophages at the inoculation site. Wild-caught SGH also determined lower production of IL-4 and IL-10 but higher IL-12 levels compared with laboratory-reared SGH. Our findings address a probable bias by using SGH from laboratory-colonized sand flies instead of wild-caught vector SGH in studies concerning saliva effects. A possible mild influence of sand fly saliva in natural infections caused by Leishmania is also speculated, as infection is transmitted by wild and not by laboratory-reared vectors
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