Author | Firmino, Alisson de Aquino | |
Author | Gomes Filho, Paulo Roberto Tavares | |
Author | Martins, Adenilda Lima Lopes | |
Author | Araújo, Thessika Hialla | |
Author | Gois, Luana Leandro | |
Author | Batista, Everton da Silva | |
Author | Araújo, Jean Paulo Lacerda | |
Author | Castro, Bernardo Galvão | |
Author | Grassi, Maria Fernanda Rios | |
Access date | 2023-06-07T13:48:18Z | |
Available date | 2023-06-07T13:48:18Z | |
Document date | 2023 | |
Citation | FIRMINO, Alisson de Aquino et al. HTLV-1 proviral load in vaginal fluid correlates with levels in peripheral blood mononuclear cells. Pathogens, v. 12, p. 1-10, 2023. | en_US |
ISSN | 2076-0817 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58968 | |
Sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES).
Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
Fundação Nacional para o Desenvolvimento do Ensino Superior Privado (FUNADESP).
Conselho Nacional de Desenvolvimento Científico e Tecnológico ( CNPq). | en_US |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Subject in Portuguese | HTLV-1 | en_US |
Subject in Portuguese | Carga proviral | en_US |
Subject in Portuguese | Carga proviral vaginal | en_US |
Title | HTLV-1 proviral load in vaginal fluid correlates with levels in peripheral blood mononuclear cells | en_US |
Type | Article | en_US |
DOI | 10.3390/pathogens12050682 | |
Abstract | Background: The prevalence of human T-lymphotropic virus type-1 (HTLV-1) infection is higher in women, and sexual intercourse has been described as an important route of male-to-female transmission. The present study aimed to quantify HTLV-1 proviral load (PVL) in vaginal fluid, and to investigate correlations with PVL in peripheral blood mononuclear cells (PBMCs). In addition, cytopathological alterations and vaginal microbiota were evaluated. Methods: HTLV-1-infected women were consecutively recruited at a multidisciplinary center for HTLV patients in Salvador, Brazil. All women underwent gynecological examinations to obtain cervicovaginal fluid and venipuncture for blood collection. PVL, as measured by real-time quantitative polymerase chain reaction (RT–qPCR), was expressed as the number of copies of HTLV-1/106 cells in blood and vaginal fluid samples. Light microscopy was used to assess cervicovaginal cytopathology and vaginal microbiota. Results: In the 56 included women (43 asymptomatic carriers and 13 diagnosed with HTLV-1-associated myelopathy/tropical spastic paraparesis—HAM/TSP), mean age was 35.9 (SD ± 7.2) years. PVL was higher in PBMCs (median: 23,264 copies/106 cells; IQR: 6776–60,036) than in vaginal fluid (451.9 copies/106 cells; IQR: 0–2490) (p < 0.0001). PVL in PBMCs was observed to correlate directly with PVL in vaginal fluid (R = 0.37, p = 0.006). PVL was detected in the vaginal fluid of 24 of 43 (55.8%) asymptomatic women compared to 12 of 13 (92.3%) HAM/TSP patients, p = 0.02. Cytopathologic analyses revealed no differences between women with detectable or undetectable PVL. Conclusion: HTLV-1 proviral load is detectable in vaginal fluid and correlates directly with proviral load in peripheral blood. This finding suggests that sexual transmission of HTLV-1 from females to males may occur, as well as vertical transmission, particularly in the context of vaginal delivery. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
Affilliation | Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo Multidisciplinar HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil. | en_US |
Subject | HTLV-1 | en_US |
Subject | Proviral load | en_US |
Subject | Vaginal proviral load | en_US |
DeCS | Vírus Linfotrópico T Tipo 1 Humano | en_US |
DeCS | Integração viral | en_US |