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HEPATITIS B VIRUS GENOTYPE D: AN OVERVIEW OF MOLECULAR EPIDEMIOLOGY, EVOLUTIONARY HISTORY, AND CLINICAL CHARACTERISTICS
Genótipo D
Subgenótipos
Distribuição geográfica
Mutações
Evolução
Genotype D
Subgenotypes
Geographic distribution
Mutations
Evolution
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular e Parasitologia. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
The hepatitis B virus (HBV) genotype D (HBV/D) is the most extensively distributed
genotype worldwide with distinct molecular and epidemiological features. This report provides an
up-to-date review on the history of HBV/D subgenotyping and misclassifications, along with largescale
analysis of over 1000 HBV/D complete genome sequences, with the aim of gaining a thorough
understanding of the global prevalence and geographic distribution of HBV/D subgenotypes. We
have additionally explored recent paleogenomic findings, which facilitated the detection of HBV/D
genomes dating back to the late Iron Age and provided new perspectives on the origins of modern
HBV/D strains. Finally, reports on distinct disease outcomes and responses to antiviral therapy
among HBV/D subgenotypes are discussed, further highlighting the complexity of this genotype
and the importance of HBV subgenotyping in the management and treatment of hepatitis B.
Palabras clave en portugues
Vírus da Hepatite BGenótipo D
Subgenótipos
Distribuição geográfica
Mutações
Evolução
Palabras clave en ingles
Hepatitis B virusGenotype D
Subgenotypes
Geographic distribution
Mutations
Evolution
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