Autor | Souza, R. M. | |
Autor | Freitas, Luiz Antonio Rodrigues de | |
Autor | Lyra, André de Castro | |
Autor | Moraes, C. F. | |
Autor | Braga, Eduardo Lorens | |
Autor | Lyra, Luiz Guilherme Costa | |
Data de acesso | 2012-12-10T18:13:16Z | |
Data de disponibilização | 2012-12-10T18:13:16Z | |
Data do publicação | 2006 | |
Citação | SOUZA, R. M. et al. Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection. Brazilian Journal of Medical Biological Researc = Revista Brasileira de Pesquisas Médicas e Biológicas, v. 39, n. 1, p. 79-83, jan. 2006. | pt_BR |
ISSN | 0100-879X | |
URI | https://www.arca.fiocruz.br/handle/icict/5949 | |
Idioma | eng | pt_BR |
Direito Autoral | open access | pt_BR |
Título | Effect of iron overload on the severity of liver histologic alterations and on the response to interferon and ribavirin therapy of patients with hepatitis C infection | pt_BR |
Tipo do documento | Article | pt_BR |
Resumo em Inglês | The objective of the present study was to determine the presence of hepatic iron overload in patients with chronic HCV infection and to correlate it with histologic alterations, HCV genotype and response to therapy. Liver tissue samples from 95 patients with chronic hepatitis C were divided into two groups: group I, presence of iron overload in hepatic tissue (Perls' staining) and group II, no iron overload. Hepatic iron overload was detected in 30 (31.6 percent) of 95 patients. Of the 69 patients tested by genotyping, 49 (71.01 percent) were genotype 1 and 20 (28.99 percent) genotype non-1. Iron overload was detected in 14 (28.6 percent) patients with genotype 1 and in 6 (30 percent) with genotype non-1 (P = 0.906). There was a significant difference in fibrosis stage between groups (P = 0.005). In group I (N = 30), one patient had stage F0/F1 of fibrosis, while in group II (N = 65), 22 (33.8 percent) patients had minimal or no fibrosis. Fibrosis stage F2/F3 was observed in 70 percent of group I patients compared to 46.2 percent of group II. Eighty-five patients were treated with a combination of interferon and ribavirin; 29 of them (34.1 percent) had a sustained virologic response and 8 (27.6 percent) of them had hepatic iron overload. Iron overload was detected in 18 (32.1 percent) of the 56 non-responders (P = 0.73). Hepatic iron overload was frequent among patients with chronic hepatitis C and was associated with a more severe stage of liver fibrosis. There was no association between iron overload and HCV genotype and response to interferon and ribavirin therapy. | pt_BR |
Afiliação | Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil | pt_BR |
Afiliação | Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil | pt_BR |
Afiliação | Hospital São Rafael. Serviço de Gastro-Hepatologia. Salvador, Bahia, Btasil | pt_BR |
Afiliação | Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil | pt_BR |
Afiliação | Universidade Federal da Bahia. Hospital Prof. Edgard Santos. Salvador, Bahia, Brasil | pt_BR |
Palavras-chave em inglês | Hepatitis C infection | pt_BR |
Palavras-chave em inglês | Iron overload | pt_BR |
Palavras-chave em inglês | Genotype | pt_BR |
Palavras-chave em inglês | Inflammatory activity | pt_BR |
Palavras-chave em inglês | Fibrosis | pt_BR |
Palavras-chave em inglês | Antiviral therapy | pt_BR |
Palavras-chave em inglês | virina/uso terapêutico | pt_BR |
Palavras-chave em inglês | Hepatite C Crônica/quimioterapia | pt_BR |
DeCS | Hepatite C Crônica/complicações | pt_BR |
DeCS | Sobrecarga de Ferro/complicações | pt_BR |
DeCS | Interferon alfa/uso terapêutico | pt_BR |
DeCS | Antivirais/uso terapêutico | pt_BR |
DeCS | Hepatite C Crônica/patologia | pt_BR |
DeCS | Hepacivirus/genética | pt_BR |
DeCS | Hepacivirus/efeitos de drogas | pt_BR |
DeCS | Reação em Cadeia da Polimerase | pt_BR |
DeCS | Quimioterapia Combinada | pt_BR |
DeCS | Índice de Gravidade de Doença | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Idoso | pt_BR |