Por favor, use este identificador para citar o enlazar este ítem:
https://www.arca.fiocruz.br/handle/icict/59584
Tipo
ArtículoDerechos de autor
Acceso restringido
Fecha del embargo
2030-12-31
Colecciones
Metadatos
Mostrar el registro completo del ítem
WHAT IS NEW? RECENT KNOWLEDGE ON FUNGAL EXTRACELLULAR VESICLES
Fungal pathogens
Intercellular communication
Secretion
Afiliación
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brazil.
Resumen en ingles
Purpose of Review Fungal extracellular vesicles (EVs) were first characterized a decade ago. Knowledge in this field expanded rapidly and although several questions remain unanswered, it is now clear that EVs play fundamental biological roles in fungi. In this manuscript, we update the reader with the most recent information on the participation of EVs in fungal physiology and pathogenesis. Recent Findings Fungal EVs were initially associated with the transport of macromolecules across the cell wall and extracellular delivery of virulence factors. However, recent findings indicate that they might also participate in prion transmission, response to nutrient availability, RNA export, morphological transition, and stimulation of different phagocytes. Summary The recent literature on fungal EVs reinforces the perception that these compartments are involved in intercellular communication and may represent interesting targets for antifungal development and tools for the generation of fungal vaccines.
Palabras clave en ingles
Extracellular vesiclesFungal pathogens
Intercellular communication
Secretion
Compartir