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THE MULTIFUNCTIONAL FUNGAL ERGOSTEROL
Saccharomyces cerevisiae
Antifungal agents
Ergosterol
Fungi
Immunity
Rodrigues, Marcio L. | Data do documento:
2018
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets. In combination, those two reports strongly indicate that the biological relevance of ergosterol is broader than the current literature suggests.
Palavras-chave em inglês
Candida albicansSaccharomyces cerevisiae
Antifungal agents
Ergosterol
Fungi
Immunity
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