Author | Rodrigues, Marcio L. | |
Access date | 2023-07-18T08:16:21Z | |
Available date | 2023-07-18T08:16:21Z | |
Document date | 2018 | |
Citation | RODRIGUES, Marcio L. The multifunctional fungal ergosterol. mBio, v. 9, n. 5, p. 1-5, e01755-18, Sept. 2018. | en_US |
ISSN | 2150-7511 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59648 | |
Language | eng | en_US |
Publisher | American Society for Microbiology | en_US |
Rights | open access | en_US |
MeSH | Antifungal Agents | en_US |
MeSH | Candida albicans | en_US |
MeSH | Ergosterol | en_US |
MeSH | Macrophages | en_US |
MeSH | Microbial Sensitivity Tests | en_US |
MeSH | Pyroptosis | en_US |
MeSH | Saccharomyces cerevisiae | en_US |
Title | The multifunctional fungal ergosterol | en_US |
Type | Article | en_US |
DOI | 10.1128/MBIO.01755-18 | |
Abstract | The roles of ergosterol in the regulation of membrane fluidity and structure, as well its role as a target for the activity of antifungals, have been known for decades. Two recent studies, however, demonstrated that ergosterol is an immunologically active lipid that induces pyroptosis and that virtually all steps of its biosynthetic process are potential drug targets. In combination, those two reports strongly indicate that the biological relevance of ergosterol is broader than the current literature suggests. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brazil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | Candida albicans | en_US |
Subject | Saccharomyces cerevisiae | en_US |
Subject | Antifungal agents | en_US |
Subject | Ergosterol | en_US |
Subject | Fungi | en_US |
Subject | Immunity | en_US |
e-ISSN | 2150-7511 | |