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LEARNING THE LANGUAGE OF PATHOGENS: PARASITES CAN USE EXTRACELLULAR VESICLES AND CELLULAR PROJECTIONS CALLED CYTONEMES TO COMMUNICATE WITH ONE ANOTHER
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Universidade Federal do Paraná. Programa de Pós-Graduação em Biologia Celular e Molecular. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Resumen en ingles
The experiments provide solid evidence of the participation of extracellular vesicles in communications between parasites, as well as the presence of specific membranous structures that allow this communication. The finding that parasites of different strains communicate with one another raises fundamental questions related to parasitism and the pathology of Trichomonas. Why do poorly adherent strains have a greater effect on the formation of cytonemes by adherent strains than their own strain? Do the secreted extracellular vesicles signal the presence of another strain, alerting nearby parasites to enhance their adherence in order to outcompete competitors? Future work should also investigate the role of microbiota and infections that often occur alongside Trichomonas.
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