Author | Rosado-de-Castro, Paulo Henrique | |
Author | Pereira-de-Carvalho, Thiago | |
Author | Barreto, Miriam Menna | |
Author | Kritski, Afranio Lineu | |
Author | Souza, Rebecca de Oliveira | |
Author | Almeida, Sergio Altino de | |
Author | Rolla, Valeria Cavalcanti | |
Author | Zin, Walter Araujo | |
Author | Carvalho, Alysson Roncally Silva | |
Author | Rodrigues, Rosana Souza | |
Access date | 2023-07-27T02:50:06Z | |
Available date | 2023-07-27T02:50:06Z | |
Document date | 2022 | |
Citation | ROSADO-DE-CASTRO, Paulo Henrique et al. Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis. The American Journal of Tropical Medicine and Hygiene, v. 106, n. 5, p. 1340-1344, Apr. 2022. | en_US |
ISSN | 0002-9637 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59800 | |
Language | eng | en_US |
Publisher | American Society of Tropical Medicine and Hygiene | en_US |
Rights | open access | en_US |
Title | Comparison of 68Ga-DOTATOC and 18F-FDG Thoracic Lymph Node and Pulmonary Lesion Uptake Using PET/CT in Postprimary Tuberculosis | en_US |
Type | Article | en_US |
DOI | 10.4269/ajtmh.21-0416 | |
Abstract | Tuberculosis (TB) remains one of the world's leading infectious cause of morbidity and mortality. Positron emission tomography (PET) associated with computed tomography (CT) allows a structural and metabolic evaluation of TB lesions, being an excellent noninvasive alternative for understanding its pathogenesis. DOTATOC labeled with gallium-68 (68Ga-DOTATOC) can bind to somatostatin receptors present in activated macrophages and lymphocytes, cells with a fundamental role in TB pathogenesis. We describe 68Ga-DOTATOC uptake distribution and patterns in thoracic lymph nodes (LN) and pulmonary lesions (PL) in immunocompetent patients with active postprimary TB, analyze the relative LN/PL uptake, and compare this two tracer's uptake. High uptake of both radiotracers in PL and LN was demonstrated, with higher LN/PL ratio on 68Ga-DOTATOC (P < 0.05). Considering that LN in immunocompetent patients are poorly studied, 68Ga-DOTATOC can contribute to the understanding of the complex immunopathogenesis of TB. | en_US |
Affilliation | D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Biomedical Sciences. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil / Petropolis School of Medicine/Arthur Sá Earp Neto Faculty. Department of Internal Medicine. Petropolis, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. School of Medicine. Academic Tuberculosis Program. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Department of Statistical Methods. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory on Mycobacteria. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Respiration Physiology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Respiration Physiology. Rio de Janeiro, RJ, Brazil / University of Porto. Faculty of Medicine. Department of Surgery and Physiology. Cardiovascular R&D Centre (UnIC). Porto, Portugal / Federal University of Rio de Janeiro. Alberto Luiz Coimbra Institute of Post-Graduation and Research in Engineering. Biomedical Engineering Program. Laboratory of Pulmonary Engineering. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | D'Or Institute for Research and Education. Department of Internal Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. Department of Radiology. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Tuberculosis | en_US |
Subject | Computed tomography (CT) | en_US |
Subject | Ga-DOTATOC | en_US |
Subject | Thoracic Lymph Node | en_US |
Subject | Pulmonary Lesion | en_US |
e-ISSN | 1476-1645 | |