Author | Filgueiras, Priscilla Soares | |
Author | Corsini, Camila Amormino | |
Author | Almeida, Nathalie Bonatti Franco | |
Author | Assis, Jéssica Vieira De | |
Author | Pedrosa, Maria Luysa de Camargos | |
Author | Oliveira, Alana Karen de | |
Author | Vilela, Raquel VR | |
Author | Miranda, Daniel AP de | |
Author | Silva, Raphael A | |
Author | Coutinho, Lucélia A | |
Author | Gomes, Sarah VC | |
Author | Custódio, Natália G | |
Author | Silva, Douglas H da | |
Author | Santos, Gabriela PV | |
Author | Medeiros, Maria Izabella VARC | |
Author | Reis, Priscila VCC | |
Author | Lourenço, Adelina J | |
Author | Bicalho, Cecília MF | |
Author | Neves, Hércules P | |
Author | Fernandes, Gabriel Rocha | |
Author | Queiroz, Rafaella Fortini Grenfell e | |
Access date | 2023-08-07T17:11:56Z | |
Available date | 2023-08-07T17:11:56Z | |
Document date | 2022 | |
Citation | FILGUEIRAS, Priscilla Soares et al. COVID-19 Rapid Antigen Test at Hospital Admission Associated to the Knowledge of Individual Risk Factors Allow Overcoming the Difficulty of Managing Suspected Patients in Hospitals. Fortune Journal Of Health Sciences, v. 05, n. 02, p. 211-231, 2022. Doi: http://dx.doi.org/10.26502/fjhs.055 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59908 | |
Language | eng | en_US |
Publisher | BMJ Yale | en_US |
Rights | restricted access | en_US |
Title | COVID-19 Rapid Antigen Test at Hospital Admission Associated to the Knowledge of Individual Risk Factors Allow Overcoming the Difficulty of Managing Suspected Patients in Hospitals. | en_US |
Type | Article | en_US |
Abstract | Early diagnosis of SARS-CoV-2 is essential to limiting the spread of the virus and managing infected patients during hospitalization. The sensitivity of RT-qPCR is contested by the fact that it is time-consuming, executed by trained technicians in proper environment for material extraction. Here, we evaluated the first SARS-CoV-2 antigen test recommended by the World Health Organization at September, 2020 as an alternative for immediate diagnosis of symptomatic and suspected patients at a hospital in Brazil during the epidemic peak. All patients were submitted to RT-qPCR and rapid antigen test using nasopharyngeal swabs rigorously collected at the same time. Demographics, baseline comorbidities, symptoms and outcomes were considered. Prediction analysis revealed that previous stroke, chronic obstructive pulmonary disease, desaturation and tachypnea were the most relevant determinants of the death of COVID-19 patients. Comparison between the rapid antigen test and RT-qPCR revealed an overall PPV of 97%, extended to 100% when performed between 4 and 15 days of symptoms, with an accuracy of 90-91% from days 1 to 7 and a ‘Substantial’ agreement. The rapid antigen test presented no inconclusive result. Among the discordant results and RT-qPCR inconclusives, 72% presented bilateral multifocal ground-glass opacities on imaging and other exams alterations. The median time to obtain RT-qPCR results was 83.6 hours, against 15 minutes for the rapid test, precious time for deciding on patient isolation and management. Knowledge of the risk factors and a rapid diagnosis upon patient admission is critical to reduce mortality of COVID-19 patients, hospital internal costs and in-hospital transmission. | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Baleia Hospital. Benjamin Guimarães Foundation. Belo Horizonte, MG. Brasil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Baleia Hospital. Benjamin Guimarães Foundation. Belo Horizonte, MG. Brasil | en_US |
Affilliation | Baleia Hospital. Benjamin Guimarães Foundation. Belo Horizonte, MG. Brasil | en_US |
Affilliation | Baleia Hospital. Benjamin Guimarães Foundation. Belo Horizonte, MG. Brasil | en_US |
Affilliation | Biosystems Informatics. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Baleia Hospital. Benjamin Guimarães Foundation. Belo Horizonte, MG. Brasil | en_US |
Affilliation | Baleia Hospital. Benjamin Guimarães Foundation. Belo Horizonte, MG. Brasil | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Biosystems Informatics. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Diagnosis and Therapy of Infectious Diseases and Cancer. Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Institute of Biological Sciences. Federal University of Minas Gerais. Belo Horizonte, MG, Brasil/Department of Infectious Diseases. College of Veterinary Medicine. University of Georgia. Athens, GA Uniteded States of America. | en_US |
Embargo date | 2099-12-31 | |