Author | Sodré, Maisah Meyhr D’Carmo | |
Author | Santos, Uener Ribeiro dos | |
Author | Povoas, Heitor Portella | |
Author | Guzmán, Júlio Lenin | |
Author | Giusta, Caroline Junqueira | |
Author | Trindade, Tayana Oliveira | |
Author | Gadelha, Sandra Rocha | |
Author | Romano, Carla Cristina | |
Author | Conceição, Aline Oliveira da | |
Author | Gross, Eduardo | |
Author | Silva, Aline | |
Author | Rezende, Rachel Passos | |
Author | Fontana, Renato | |
Author | Mata, Camila Pacheco Silveira Martins da | |
Author | Marin, Lauro Juliano | |
Author | Carvalho, Luciana Debortoli de | |
Access date | 2023-11-07T17:24:06Z | |
Available date | 2023-11-07T17:24:06Z | |
Document date | 2023 | |
Citation | D'CARMO SODRÉ, Maisah Meyhr et al. Relationship between clinical-epidemiological parameters and outcomes of patients with COVID-19 admitted to the intensive care unit: a report from a Brazilian hospital. Front Public Health, v. 11, 1241444, 2023. doi.org/10.3389/fpubh.2023.1241444. | en_US |
ISSN | 2296-2565 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/61070 | |
Language | eng | en_US |
Publisher | Frontiers Editorial Office | en_US |
Rights | restricted access | en_US |
Title | Relationship between clinical-epidemiological parameters and outcomes of patients with COVID-19 admitted to the intensive care unit: a report from a Brazilian hospital. | en_US |
Type | Article | en_US |
Abstract | Background: People in low-income countries, especially those with low socio-economic conditions, are likelier to test positive for SARS-CoV-2. The unequal conditions of public health systems also increase the infection rate and make early identification and treatment of at-risk patients difficult. Here, we aimed to characterize the epidemiological profile of COVID-19 patients in intensive care and identify laboratory and clinical markers associated with death.
Materials and methods: We conducted an observational, descriptive, and cross-sectional study in a reference hospital for COVID-19 treatment in the Southern Region of Bahia State, in Brazil, to evaluate the epidemiological, clinical, and laboratory characteristics of COVID-19 patients admitted to the intensive care unit (ICU). Additionally, we used the area under the curve (AUC) to classify survivors and non-survivors and a multivariate logistic regression analysis to assess factors associated with death. Data was collected from the hospital databases between April 2020 and July 2021.
Results: The use of bladder catheters (OR 79.30; p < 0.0001) and central venous catheters (OR, 45.12; p < 0.0001) were the main factors associated with death in ICU COVID-19 patients. Additionally, the number of non-survivors increased with age (p < 0.0001) and prolonged ICU stay (p < 0.0001). Besides, SAPS3 presents a higher sensibility (77.9%) and specificity (63.1%) to discriminate between survivors and non-survivor with an AUC of 0.79 (p < 0.0001).
Conclusion: We suggest that multi-laboratory parameters can predict patient prognosis and guide healthcare teams toward more assertive clinical management, better resource allocation, and improved survival of COVID-19 patients admitted to the ICU. | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Hospital de Ilhéus. Ilhéus, BA, Brazil | en_US |
Affilliation | Hospital de Ilhéus. Ilhéus, BA, Brazil | en_US |
Affilliation | Program in Cellular and Molecular Medicine. Boston Children's Hospital. Boston, MA, United States/Department of Pediatrics. Harvard Medical School. Boston, MA, United States/René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Hospital de Ilhéus. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Laboratory of Microbiology. Risoleta Tolentino Neves Hospital. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Department of Health. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Affilliation | Department of Biological Sciences. Santa Cruz State University. Ilhéus, BA, Brazil | en_US |
Subject | COVID-19 | en_US |
Subject | SARS-CoV-2 | en_US |
Subject | biomarkers | en_US |
Subject | epidemiology | en_US |
Subject | SAPS3 | en_US |
Subject | in-hospital mortality | en_US |
Subject | intensive care unit | en_US |
Subject | catheter | en_US |