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Autor | Dallastella, Marianna | |
Autor | Oliveira, Willian Klassen de | |
Autor | Rodrigues, Marcio Lourenço | |
Autor | Goldenberg, Samuel | |
Autor | Alves, Lysangela Ronalte | |
Fecha de acceso | 2023-11-07T18:08:10Z | |
Fecha de disponibilización | 2023-11-07T18:08:10Z | |
Fecha de publicación | 2023 | |
Referencia | DALLASTELLA, Marianna et al. The characterization of RNA-binding proteins and RNA metabolism-related proteins in fungal extracellular vesicles. Front. Cell. Infect. Microbiol. V.13, n. 1247329., p. 1-12, 2023. | en_US |
ISSN | 2235-2988 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/61075 | |
Idioma | por | en_US |
Editor | Frontiers Media | en_US |
Derechos de autor | open access | en_US |
Título | The characterization of RNAbinding proteins and RNA metabolism-related proteins in fungal extracellular vesicles | en_US |
Tipo del documento | Article | en_US |
DOI | 10.3389/fcimb.2023.1247329 | |
Resumen en Inglés | RNA-binding proteins (RBPs) are essential for regulating RNA metabolism, stability, and translation within cells. Recent studies have shown that RBPs are not restricted to intracellular functions and can be found in extracellular vesicles (EVs) in different mammalian cells. EVs released by fungi contain a variety of proteins involved in RNA metabolism. These include RNA helicases, which play essential roles in RNA synthesis, folding, and degradation. Aminoacyl-tRNA synthetases, responsible for acetylating tRNA molecules, are also enriched in EVs, suggesting a possible link between these enzymes and tRNA fragments detected in EVs. Proteins with canonical RNA-binding domains interact with proteins and RNA, such as the RNA Recognition Motif (RRM), Zinc finger, and hnRNP K-homology (KH) domains. Polyadenylate-binding protein (PABP) plays a critical role in the regulation of gene expression by binding the poly(A) tail of messenger RNA (mRNA) and facilitating its translation, stability, and localization, making it a key factor in post-transcriptional control of gene expression. The presence of proteins related to the RNA life cycle in EVs from different fungal species suggests a conserved mechanism of EV cargo packing. Various models have been proposed for selecting RNA molecules for release into EVs. Still, the actual loading processes are unknown, and further molecular characterization of these proteins may provide insight into the mechanism of RNA sorting into EVs. This work reviews the current knowledge of RBPs and proteins related to RNA metabolism in EVs derived from distinct fungi species, and presents an analysis of proteomic datasets through GO term and orthology analysis, Our investigation identified orthologous proteins in fungal EVs on different fungal species. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Regulação da Expressão Gênica. Curitiba, PR, Brasil. / Research Center in Infectious Diseases. Division of Infectious Disease and Immunity CHU de Quebec Research Center. University Laval, Québec City, Canada. | en_US |
Palavras clave en Inglês | Extracellular Vesicles | en_US |
Palavras clave en Inglês | RNA-Binding Proteins | en_US |
Palavras clave en Inglês | Metabolism | en_US |
Palavras clave en Inglês | Proteomics | en_US |
Palavras clave en Inglês | Cell Communication | en_US |
Palavras clave | Vesículas Extracelulares | en_US |
Palavras clave | Proteínas de Unión al ARN | en_US |
Palavras clave | Metabolismo | en_US |
Palavras clave | Proteómica | en_US |
Palavras clave | Comunicación Celular | en_US |
Palavras clave en Francês | Vésicules extracellulaires | en_US |
Palavras clave en Francês | Protéines de liaison à l'ARN | en_US |
Palavras clave en Francês | Métabolisme | en_US |
Palavras clave en Francês | Protéomique | en_US |
Palavras clave en Francês | Communication cellulaire | en_US |
DeCS | Vesículas Extracelulares | en_US |
DeCS | Proteínas de Ligação a RNA | en_US |
DeCS | Metabolismo | en_US |
DeCS | Proteômica | en_US |
DeCS | Comunicação Celular | en_US |