Author | Siqueira, Isadora Cristina de | |
Author | Almeida, Breno Lima de | |
Author | Lage, Maria Lucia Costa | |
Author | Serra, Leticia | |
Author | Carvalho, Alessandra | |
Author | Lima, Maricélia Maia de | |
Author | Góes, Maria de Fatima Neri | |
Author | Crispim, Marília De Santa Inês Neri | |
Author | Pereira, Mirela Monteiro da Costa | |
Author | Costa, Bernardo Gratival Gouvea | |
Author | Bailey, Heather | |
Author | Byrne, Thomas | |
Author | Giaquinto, Carlo | |
Author | Fernandes, Georgina | |
Author | Ruiz-Burga, Elisa | |
Author | Thorne, Claire | |
Access date | 2023-11-14T15:02:46Z | |
Available date | 2023-11-14T15:02:46Z | |
Document date | 2023 | |
Citation | SIQUEIRA, Isadora Cristina de et al. Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction paediatric registry. Dialogues in Health, v. 2, p. 1-7, 2023. | en_US |
ISSN | 2772-6533 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/61305 | |
Sponsorship | European Union Horizon 2020 programme. | en_US |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | en_US |
Subject in Portuguese | Síndrome Congênita do Zika | en_US |
Subject in Portuguese | Microcefalia | en_US |
Subject in Portuguese | Neurodesenvolvimento | en_US |
Subject in Portuguese | Vírus Zika | en_US |
Title | Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction paediatric registry | en_US |
Type | Article | en_US |
DOI | 10.1016/j.dialog.2023.100104 | |
Abstract | Background: Despite growing scientific knowledge of Zika virus (ZIKV) infection, questions remain regarding ZIKV infection in pregnancy and congenital ZIKV syndrome (CZS). Methods: The ZIKAction Paediatric Registry is an international registry of children with documented ZIKV exposure in utero and/or with confirmed or suspected CZS. Its aim is to characterize these children (i.e., clinical, radiological, neurodevelopmental features) and describe outcomes, longer-term sequelae and management through retrospective case note review. This analysis described the maternal and perinatal characteristics of children in the Registry’s Bahia arm, assessed their neuroimaging, ophthalmic, hearing and electroencephalography abnormalities by microcephaly classification and reported on hospitalisations. Children born in 2015-2018 and enrolled 2020-2021 in three public health facilities in Salvador were included. Results: Of 129 (57% female) children, 15 (11·6%) had laboratory-confirmed congenital ZIKV infection and 114 (88·4%) suspected CZS. At delivery, 15 (11·6%) were normocephalic, 30 (23·3%) moderately microcephalic, and 84 (65·1%) severely microcephalic. Median birth head circumference z-score was -3·51 [IQR, -4·69,-2·73]. During follow-up, all children had abnormal neuroimaging, 80·3% (94/117) abnormal electroencephalogram, 62·2% (77/120) ophthalmic abnormalities, and 27·4% (34/124) hearing impairment. Microcephaly classification was significantly associated with gestational age, and ophthalmological and electroencephalography abnormalities. Of 125 children with hospitalisation data, 52 (41·6%) had been hospitalised by most recent follow-up, at median age of 15·8 [4·0, 34·4] months; infections were the leading cause. Conclusion: Congenital ZIKV infection is an emerging disease with a varied and incompletely understood spectrum. Continued long-term follow-up is essential to understand longer-term prognosis and to inform future health and educational needs. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Centro de Prevenção e Reabilitação da Pessoa com Deficiência. Salvador, BA, Brasil. | en_US |
Affilliation | Rede SARAH de Hospitais de Reabilitação. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil. | en_US |
Affilliation | Instituto Cegos da Bahia. Salvador, BA, Brasil. | en_US |
Affilliation | Instituto Cegos da Bahia. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | UCL Institute for Global Health. University College London. Mortimer Market Centre. London, UK. | en_US |
Affilliation | UCL Great Ormond Street Institute of Child Health. GOSH NIHR BRC. London, UK. | en_US |
Affilliation | Division of Paediatric Infectious Diseases. Department for Woman and Child Health. University of Padova. Padova, Italy. | en_US |
Affilliation | UCL Great Ormond Street Institute of Child Health. GOSH NIHR BRC. London, UK. | en_US |
Affilliation | UCL Institute for Global Health. University College London. Mortimer Market Centre. London, UK / UCL Great Ormond Street Institute of Child Health. GOSH NIHR BRC. London, UK. | en_US |
Affilliation | UCL Great Ormond Street Institute of Child Health. GOSH NIHR BRC. London, UK. | en_US |
Subject | Congenital Zika Syndrome | en_US |
Subject | Microcephaly | en_US |
Subject | Neurodevelopment | en_US |
Subject | Zika Virus | en_US |
DeCS | Infecção por Zika virus | en_US |
DeCS | Microcefalia | en_US |
DeCS | Transtornos do Neurodesenvolvimento | en_US |
DeCS | Zika virus | en_US |