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3100-12-31
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GENETIC AND STRUCTURAL ANALYSES REVEAL THE LOW POTENTIAL OF THE SARS-COV-2 EG.5 VARIANT.
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Department of Biomedical Sciences. University of Sassari. Sassari, Italy.
Department of Biochemical Sciences "A. Rossi Fanelli". Sapienza Università di Roma. Rome, Italy.
Unit of Medical Statistics and Molecular Epidemiology. Università Campus Bio-Medico di Roma. Rome, Italy.
Department of Science and Technology for Humans and the Environment. Università Campus Bio-Medico di Roma. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo, Horizonte, MG, Brazil.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy/Department of Veterinary Medicine. University of Sassari. Sassari, Italy.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy/Department of Veterinary Medicine. University of Sassari. Sassari, Italy.
Department of Veterinary Medicine. University of Sassari. Sassari, Italy.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy/Azienza Ospedaliera Universitaria Sassari. Sassari, Italy.
Department of Biochemical Sciences "A. Rossi Fanelli". Sapienza Università di Roma. Rome, Italy.
Burnett School of Biomedical Sciences. University of Central Florida. Orlando, Florida, USA.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy.
Unit of Medical Statistics and Molecular Epidemiology. Università Campus Bio-Medico di Roma. Rome, Italy.
Department of Biochemical Sciences "A. Rossi Fanelli". Sapienza Università di Roma. Rome, Italy.
Unit of Medical Statistics and Molecular Epidemiology. Università Campus Bio-Medico di Roma. Rome, Italy.
Department of Science and Technology for Humans and the Environment. Università Campus Bio-Medico di Roma. Rome, Italy/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo, Horizonte, MG, Brazil.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy/Department of Veterinary Medicine. University of Sassari. Sassari, Italy.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy/Department of Veterinary Medicine. University of Sassari. Sassari, Italy.
Department of Veterinary Medicine. University of Sassari. Sassari, Italy.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy/Azienza Ospedaliera Universitaria Sassari. Sassari, Italy.
Department of Biochemical Sciences "A. Rossi Fanelli". Sapienza Università di Roma. Rome, Italy.
Burnett School of Biomedical Sciences. University of Central Florida. Orlando, Florida, USA.
Department of Biomedical Sciences. University of Sassari. Sassari, Italy.
Unit of Medical Statistics and Molecular Epidemiology. Università Campus Bio-Medico di Roma. Rome, Italy.
Abstract
The severe acute respiratory syndrome coronavirus 2 EG.5 lineage is the latest variant under monitoring, and it is generating significant concern due to its recent upward trend in prevalence. Our aim was to gain insights into this emerging lineage and offer insights into its actual level of threat. Both genetic and structural data indicate that this novel variant presently lacks substantial evidence of having a high capacity for widespread transmission. Their viral population sizes expanded following a very mild curve and peaked several months after the earliest detected sample. Currently, neither the viral population size of EG.5 nor that of its first descendant is increasing. The genetic variability appear to be flattened, as evidenced by its relatively modest evolutionary rate (9.05 × 10-4 subs/site/year). As has been observed with numerous prior variants, attributes that might theoretically provide advantages seem to stem from genetic drift, enabling the virus to continually adjust to its host, albeit without a clear association with enhanced dangerousness. These findings further underscore the necessity for ongoing genome-based monitoring, ensuring preparedness and a well-documented understanding of the unfolding situation.
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