Author | Gomes, Rachel da Silva Ribeiro | |
Author | Valle, Antonio Carlos Francesconi do | |
Author | Freitas, Dayvison Francis Saraiva | |
Author | Macedo, Priscila Marques de | |
Author | Oliveira, Raquel de Vasconcellos Carvalhaes | |
Author | Almeida-Paes, Rodrigo | |
Author | Zancopé-Oliveira, Rosely Maria | |
Author | Gutierrez-Galhardo, Maria Clara | |
Access date | 2023-11-29T02:43:36Z | |
Available date | 2023-11-29T02:43:36Z | |
Document date | 2023 | |
Citation | GOMES, Rachel da Silva Ribeiro et al. Sporotrichosis in Older Adults: A Cohort Study of 911 Patients from a Hyperendemic Area of Zoonotic Transmission in Rio de Janeiro, Brazil. Journal of Fungi, v. 9, n. 8, p. 1-16, 2023. | en_US |
ISSN | 2309-608X | |
URI | https://www.arca.fiocruz.br/handle/icict/61541 | |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Sporotrichosis in Older Adults: A Cohort Study of 911 Patients from a Hyperendemic Area of Zoonotic Transmission in Rio de Janeiro, Brazil | en_US |
Type | Article | en_US |
DOI | 10.3390/jof9080804 | |
Abstract | Generally, older people tend to suffer from more severe infections than younger adults. In addition, there are accumulations of comorbidities and immune senescence in some cases. This cohort study evaluated the clinical and epidemiological characteristics of older adults (≥60 years old) with sporotrichosis. The cohort consisted of 911 patients with a median age of 67 years, most of whom were female (72.6%), white (62.1%), and afflicted with comorbidities (64.5%). The lymphocutaneous form occurred in 62% of the patients, followed by the fixed form (25.7%), cutaneous disseminated form (8.9%), and extracutaneous/disseminated forms (3.3%). In this study, we draw attention to the frequency of osteoarticular involvement (2.1%) secondary to skin lesions such as osteomyelitis and/or tenosynovitis. A clinical cure was achieved in 87.3% of cases. Itraconazole was used in 81.1% of cases, while terbinafine was used in 22.7% of cases, usually in low doses. Survival analysis showed
that the median treatment time was 119 days, and the multiple Cox model demonstrated that the presentation of a black coloration and diabetes was associated with a longer treatment time required to establish a cure. Therefore, these subgroups should be monitored more closely to reduce possible difficulties during treatment. It would be interesting to conduct more studies analyzing older adults with sporotrichosis from different geographic areas to better comprehend the disease in this group. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Epidemiology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Sporotrichosis | en_US |
Subject | Older adults | en_US |
Subject | Zoonotic | en_US |
Subject | Sporothrix brasiliensis | en_US |
Subject | Osteoarticular form | en_US |
Subject | Itraconazole | en_US |
Subject | Terbinafine | en_US |
Subject | Cryosurger | en_US |
e-ISSN | 2309-608X | |