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THE MATING TYPE (MAT) AND VIRULENCE OF SPOROTHRIX SCHENCKII SENSU STRICTO ISOLATES MAINTAINED IN CULTURE COLLECTION
Preservation in culture collection
Mating type
Virulence/Pathogenicity
Autor(es)
Afiliação
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory and Facility Multi-User. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Dermatozoonoses in Domestic Animals. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi. Rio de Janeiro, RJ, Brazil.
Resumo em Inglês
In an attempt to determine the mating type of different Sporothrix schenckii sensu stricto isolates that remained viable after a long period of preservation in a culture collection and to correlate them with the degree of virulence/pathogenicity, a PCR technique using primers designed for the sequences of MAT1-1-1 and MAT1-2-1 genes and a murine experimental model were used. The results showed that there was no correlation between the mating type and virulence among the isolates. Furthermore, different degrees of virulence/pathogenicity, ranging from high to low, were found among them based on different virulence parameters. It was assumed that the long period of preservation favored the changes, yielding the isolation of variants. Thus, we believe that new technologies for studies on factors can improve our knowledge of the pathogenesis of sporotrichosis.
Palavras-chave em inglês
Sporothrix schenckii sensu strictoPreservation in culture collection
Mating type
Virulence/Pathogenicity
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