Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/62204
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2030-12-31
Coleções
- INI - Artigos de Periódicos [3397]
Metadata
Mostrar registro completo
AUTONOMIC DENERVATION, MYOCARDIAL HYPOPERFUSION AND FIBROSIS MAY PREDICT VENTRICULAR ARRHYTHMIA IN THE EARLY STAGES OF CHAGAS CARDIOMYOPATHY
Autonomic Denervation
Myocardial Fibrosis
Myocardial Hypoperfusion
Ventricular Arrhythmia
Autor(es)
Brito, Adriana Soares Xavier de
Moll-Bernardes, Renata Junqueira
Pinheiro, Martha Valéria Tavares
Camargo, Gabriel Cordeiro
Siqueira, Fabio Paiva Rossini
Oliveira, Renee Sarmento
Glavam, Adriana Pereira
Almeida, Sergio Altino de
Holanda, Marcelo Teixeira de
Sangenis, Luiz Henrique Conde
Mendes, Fernanda de Souza Nogueira Sardinha
Rosado-de-Castro, Paulo Henrique
Sousa, Andrea Silvestre de
Moll-Bernardes, Renata Junqueira
Pinheiro, Martha Valéria Tavares
Camargo, Gabriel Cordeiro
Siqueira, Fabio Paiva Rossini
Oliveira, Renee Sarmento
Glavam, Adriana Pereira
Almeida, Sergio Altino de
Holanda, Marcelo Teixeira de
Sangenis, Luiz Henrique Conde
Mendes, Fernanda de Souza Nogueira Sardinha
Rosado-de-Castro, Paulo Henrique
Sousa, Andrea Silvestre de
Afiliação
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil.
Resumo em Inglês
Background: Sudden cardiac death (SCD) can be the first clinical event of Chagas heart disease (CHD). However, current guidelines contain no clear recommendation for early cardioverter-defibrillator implantation. Using imaging modalities, we evaluated associations among autonomic denervation, myocardial hypoperfusion, fibrosis and ventricular arrhythmia in CHD. Methods and results: Twenty-nine patients with CHD and preserved left ventricular function underwent 123I-metaiodobenzylguanidine (MIBG) scintigraphy, 99mTc-methoxyisobutylisonitrile (MIBI) myocardial perfusion and cardiac magnetic resonance imaging (MRI). They were divided into arrhythmic (≥ 6 ventricular premature complexes/h and/or non-sustained ventricular tachycardia on 24-hour Holter, n = 15) and non-arrhythmic (< 6 ventricular premature complexes/h and no ventricular tachycardia; n = 14) groups. The arrhythmic group had higher denervation scores from MIBG imaging (23.2 ± 18.7 vs 5.6 ± 4.9; P < .01), hypoperfusion scores from MIBI SPECT (4.7 ± 6.8 vs 0.29 ± 0.6: P = .02), innervation/perfusion mismatch scores (18.5 ± 17.5 vs 5.4 ± 4.8; P = .01) and fibrosis by late gadolinium enhancement on MRI (14.3% ± 13.5% vs 4.0% ± 2.9%; P = .04) than the non-arrhythmic group. Conclusion: These imaging parameters were associated with ventricular arrhythmia in early CHD and may enable risk stratification and the implementation of primary preventive strategies for SCD.
Palavras-chave em inglês
Chagas DiseaseAutonomic Denervation
Myocardial Fibrosis
Myocardial Hypoperfusion
Ventricular Arrhythmia
Compartilhar