| Author | Brito, Adriana Soares Xavier de | |
| Author | Moll-Bernardes, Renata Junqueira | |
| Author | Pinheiro, Martha Valéria Tavares | |
| Author | Camargo, Gabriel Cordeiro | |
| Author | Siqueira, Fabio Paiva Rossini | |
| Author | Oliveira, Renee Sarmento | |
| Author | Glavam, Adriana Pereira | |
| Author | Almeida, Sergio Altino de | |
| Author | Holanda, Marcelo Teixeira de | |
| Author | Sangenis, Luiz Henrique Conde | |
| Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
| Author | Rosado-de-Castro, Paulo Henrique | |
| Author | Sousa, Andrea Silvestre de | |
| Access date | 2024-01-16T15:32:39Z | |
| Available date | 2024-01-16T15:32:39Z | |
| Document date | 2023 | |
| Citation | BRITO, Adriana Soares Xavier de et al. Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy. Journal of Nuclear Cardiology, v. 30, n. 6, p. 2379–2388, Nov./Dec. 2023. | en_US |
| ISSN | 1071-3581 | en_US |
| URI | https://www.arca.fiocruz.br/handle/icict/62204 | |
| Language | eng | en_US |
| Publisher | American Society of Nuclear Cardiology | en_US |
| Rights | restricted access | en_US |
| Title | Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy | en_US |
| Type | Article | en_US |
| DOI | 10.1007/s12350-023-03281-9 | |
| Abstract | Background: Sudden cardiac death (SCD) can be the first clinical event of Chagas heart disease (CHD). However, current guidelines contain no clear recommendation for early cardioverter-defibrillator implantation. Using imaging modalities, we evaluated associations among autonomic denervation, myocardial hypoperfusion, fibrosis and ventricular arrhythmia in CHD. Methods and results: Twenty-nine patients with CHD and preserved left ventricular function underwent 123I-metaiodobenzylguanidine (MIBG) scintigraphy, 99mTc-methoxyisobutylisonitrile (MIBI) myocardial perfusion and cardiac magnetic resonance imaging (MRI). They were divided into arrhythmic (≥ 6 ventricular premature complexes/h and/or non-sustained ventricular tachycardia on 24-hour Holter, n = 15) and non-arrhythmic (< 6 ventricular premature complexes/h and no ventricular tachycardia; n = 14) groups. The arrhythmic group had higher denervation scores from MIBG imaging (23.2 ± 18.7 vs 5.6 ± 4.9; P < .01), hypoperfusion scores from MIBI SPECT (4.7 ± 6.8 vs 0.29 ± 0.6: P = .02), innervation/perfusion mismatch scores (18.5 ± 17.5 vs 5.4 ± 4.8; P = .01) and fibrosis by late gadolinium enhancement on MRI (14.3% ± 13.5% vs 4.0% ± 2.9%; P = .04) than the non-arrhythmic group. Conclusion: These imaging parameters were associated with ventricular arrhythmia in early CHD and may enable risk stratification and the implementation of primary preventive strategies for SCD. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Affilliation | D’Or Institute for Research and Education. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
| Subject | Chagas Disease | en_US |
| Subject | Autonomic Denervation | en_US |
| Subject | Myocardial Fibrosis | en_US |
| Subject | Myocardial Hypoperfusion | en_US |
| Subject | Ventricular Arrhythmia | en_US |
| e-ISSN | 1532-6551 | |
| Embargo date | 2030-12-31 | |
