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EPIDEMIOLOGICAL AND MOLECULAR EVIDENCE OF INTRAFAMILIAL TRANSMISSION THROUGH SEXUAL AND VERTICAL ROUTES IN BAHIA, THE STATE WITH THE HIGHEST PREVALENCE OF HTLV-1 IN BRAZIL
Evidências epidemiológicas e moleculares
Transmissão sexual vertical
Prevalência
Bahia - Brasil
Epidemiological and molecular evidence
Transmission sexual vertical
Prevalence
Bahia - Brazil
Autor
Afiliación
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil.
Resumen en ingles
Introduction: Familial clustering of HTLV-1 and related diseases has been reported in Brazil. However, intrafamilial transmission of HTLV-1 based on molecular analysis has been studied only in a few communities of Japanese immigrants and African-Brazilians. Objective: To investigate the familial clustering of HTLV-1 infection and to determine the likely routes of transmission through epidemiological and genetic analyzes. Methods: Medical records of 1,759 HTLV-1+ patients from de the Center for HTLV in Salvador, Brazil, were evaluated to identify first-degree relatives previously tested for HTLV-1. Familial clustering was assumed if more than one member of the same family was HTLV-1+. LTR regions of HTLV-1 sequences were analyzed for the presence of intrafamilial polymorphisms. Family pedigrees were constructed and analyzed to infer the likely transmission routes of HTLV-1. Results: In 154 patients at least one other family member had tested positive for HTLV-1 (a total of 182 first-degree relatives). Of the 91 couples (182 individuals), 51.6% were breastfed, and 67.4% reported never using a condom. Of the 42 mother-child pairs, 23.8% had a child aged 13 years or younger; all mothers reported breastfeeding their babies. Pedigrees of families with 4 or more members suggests that vertical transmission is a likely mode of transmission in three families. Three families may have had both vertical and sexual transmission routes for HTLV-1. The genetic signatures of the LTR region of 8 families revealed 3 families with evidence of vertical transmission, another 3 families (spouses) with sexual transmission, and one family with both transmission routes. HTLV-1 sequences belonged to Cosmopolitan subtype HTLV-1a Transcontinental subgroup A. Conclusion: Sexual and vertical transmission routes contribute to the intrafamilial spread of HTLV-1 in the state of Bahia.
Palabras clave en portugues
HTLV-1Evidências epidemiológicas e moleculares
Transmissão sexual vertical
Prevalência
Bahia - Brasil
Palabras clave en ingles
HTLV-1Epidemiological and molecular evidence
Transmission sexual vertical
Prevalence
Bahia - Brazil
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