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https://www.arca.fiocruz.br/handle/icict/62365
CHIKUNGUNYA VIRUS ANTEPARTUM TRANSMISSION AND ABNORMAL INFANT OUTCOMES IN A COHORT OF PREGNANT WOMEN IN NIGERIA
Arbovírus
Gravidez
Transmissão perinatal
Anormalidade congênita
África
Arbovirus
Pregnancy
Perinatal transmission
Congenital abnormality
Africa
Arbovírus
Gravidez
Transmissão Vertical de Doenças Infecciosas
Anormalidades congênitas
África
Autor(es)
Sagay, Atiene S.
Hsieh, Szu-Chia
Dai, Yu-Ching
Chang, Charlotte Ajeong
Ogwuche, Jerry
Ige, Olukemi O.
Kahansim, Makshwar L.
Chaplin, Beth
Imade, Godwin
Elujoba, Michael
Paul, Michael
Hamel, Donald J.
Furuya, Hideki
Khouri, Ricardo
Boaventura, Viviane Sampaio
Moraes, Laíse de
Kanki, Phyllis J.
Wang, Wei-Kung
Hsieh, Szu-Chia
Dai, Yu-Ching
Chang, Charlotte Ajeong
Ogwuche, Jerry
Ige, Olukemi O.
Kahansim, Makshwar L.
Chaplin, Beth
Imade, Godwin
Elujoba, Michael
Paul, Michael
Hamel, Donald J.
Furuya, Hideki
Khouri, Ricardo
Boaventura, Viviane Sampaio
Moraes, Laíse de
Kanki, Phyllis J.
Wang, Wei-Kung
Afiliação
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA.
Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA.
Department of Immunology and Infectious Diseases.Harvard T.H. Chan School of Public Health. Boston, USA.
Our Lady of Apostles Hospital. Jos, Nigeria.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Our Lady of Apostles Hospital. Jos, Nigeria.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA.
Department of Biomedical Science. Cedars-Sinai Medical Center. Los Angeles, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA.
Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA.
Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA.
Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA.
Department of Immunology and Infectious Diseases.Harvard T.H. Chan School of Public Health. Boston, USA.
Our Lady of Apostles Hospital. Jos, Nigeria.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Our Lady of Apostles Hospital. Jos, Nigeria.
Jos University Teaching Hospital. University of Jos. Jos, Nigeria.
Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA.
Department of Biomedical Science. Cedars-Sinai Medical Center. Los Angeles, USA.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Department of Immunology and Infectious Diseases. Harvard T.H. Chan School of Public Health. Boston, USA.
Department of Tropical Medicine. Medical Microbiology and Pharmacology. John A. Burns School of Medicine. University of Hawaii at Manoa. Honolulu, USA.
Resumo em Inglês
Objectives: Chikungunya virus (CHIKV), a reemerging global public health concern, which causes acute febrile illness, rash, and arthralgia and may affect both mothers and infants during pregnancy. Mother-to-child transmission (MTCT) of CHIKV in Africa remains understudied. Methods: Our cohort study screened 1006 pregnant women with a Zika/dengue/CHIKV rapid test at two clinics in Nigeria between 2019 and 2022. Women who tested positive for the rapid test were followed through their pregnancy and their infants were observed for 6 months, with a subset tested by reverse transcription-polymerase chain reaction (RT-PCR) and neutralization, to investigate seropositivity rates and MTCT of CHIKV. Results: Of the 1006, 119 tested positive for CHIKV immunoglobulin (Ig)M, of which 36 underwent detailed laboratory tests. While none of the IgM reactive samples were RT-PCR positive, 14 symptomatic pregnant women were confirmed by CHIKV neutralization test. Twelve babies were followed with eight normal and four abnormal outcomes, including stillbirth, cleft lip/palate with microcephaly, preterm delivery, polydactyly with sepsis, and jaundice. CHIKV IgM testing identified three possible antepartum transmissions. Conclusion: In Nigeria, we found significant CHIKV infection in pregnancy and possible CHIKV antepartum transmission associated with birth abnormalities.
Palavras-chave
Vírus ChikungunyaArbovírus
Gravidez
Transmissão perinatal
Anormalidade congênita
África
Palavras-chave em inglês
Chikungunya virusArbovirus
Pregnancy
Perinatal transmission
Congenital abnormality
Africa
DeCS
Vírus ChikungunyaArbovírus
Gravidez
Transmissão Vertical de Doenças Infecciosas
Anormalidades congênitas
África
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