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Autor | Calvet, Guilherme Amaral | |
Autor | Kara, Edna Oliveira | |
Autor | Bôtto‑Menezes, Camila Helena Aguiar | |
Autor | Castilho, Marcia da Costa | |
Autor | Franca, Rafael Freitas de Oliveira | |
Autor | Habib, Ndema | |
Autor | Menezes Neto, Armando | |
Autor | Pereira, Gerson Fernando Mendes | |
Autor | Giozza, Silvana Pereira | |
Autor | Bermúdez, Ximena Pamela Díaz | |
Autor | Fernandes, Tatiana Jorge | |
Autor | Modjarrad, Kayvon | |
Autor | Brasil, Patrícia | |
Autor | Broutet, Nathalie Jeanne Nicole | |
Autor | Filippis, Ana Maria Bispo de | |
Fecha de acceso | 2024-02-04T21:08:41Z | |
Fecha de disponibilización | 2024-02-04T21:08:41Z | |
Fecha de publicación | 2023 | |
Referencia | CALVET, Guilherme Amaral et al. Detection and persistence of Zika virus in body fuids and associated factors: a prospective cohort study. Scientific Reports, v. 13, n. 1, p. 1-18, Dec. 2023. | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/62532 | |
Descripción | ZIKABRA Study Team: A list of authors and their afliations appears at the end of the paper. GuilhermeAmaral Calvet1*, Patrícia Brasil1, Tatiana Jorge Fernandes1, Edna Oliveira Kara2, Ndema Habib2, Nathalie Jeanne Nicole Broutet2, Camila HelenaAguiar Bôtto‑Menezes3,4, Marcia da Costa Castilho3, Rafael Freitas de OliveiraFranca5, Armando Menezes Neto5, Morganna Costa Lima5, Gerson Fernando Mendes Pereira6, Silvana Pereira Giozza6, Ximena Pamela Díaz Bermúdez7, Kayvon Modjarrad8 & Ana Maria Bispo de Filippis9 &. | en_US |
Idioma | eng | en_US |
Editor | Nature Publishing Group | en_US |
Derechos de autor | open access | en_US |
Título | Detection and persistence of Zika virus in body fuids and associated factors: a prospective cohort study | en_US |
Tipo del documento | Article | en_US |
DOI | 10.1038/s41598-023-48493-8 | |
Resumen en Inglés | This study aimed to analyze the detection and duration of the Zika virus (ZIKV) in plasma, urine, saliva, sweat, rectal swabs, vaginal secretions, breast milk, and semen and to explore risk factors associated with prolonged viral persistence. A prospective cohort study of symptomatic patients and their household contacts was conducted in Brazil from July 2017 to June 2019. A total of 260 individuals (184 women and 76 men) with confirmed ZIKV infection were enrolled and followed up for 12 months. ZIKV RNA was present in all body fluid specimens and detectable for extended periods in urine, sweat, rectal swabs, and semen. The longest detection duration was found in semen, with high viral loads in the specimens. ZIKV RNA clearance was associated with several factors, including age, sex, education level, body mass index, non-purulent conjunctivitis, joint pain, and whether the participant had a history of yellow fever vaccination. The influence of each of these factors on the low or fast viral clearance varied according to the specific body fluid under investigation. Recurrent ZIKV detection events after total viral clearance were observed in the cohort. Our findings provide valuable insights into the persistence and potential recurrence of ZIKV infection, highlighting the need for continued monitoring and follow-up of individuals infected with ZIKV and for effective prevention measures to reduce the risk of transmission. | en_US |
Afiliación | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Department of Sexual and Reproductive Health and Research. World Health Organization. Geneva, Switzerland. | en_US |
Afiliación | Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Department of Malaria. Manaus, AM, Brazil / Amazonas State University. School of Health Sciences. Manaus, AM, Brazil. | en_US |
Afiliación | Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Department of Malaria. Manaus, AM, Brazil. | en_US |
Afiliación | Oswaldo Cruz Foundation. Institute Aggeu Magalhães. Department of Virology and Experimental Therapy. Recife, PE Brazil. | en_US |
Afiliación | Department of Sexual and Reproductive Health and Research. World Health Organization. Geneva, Switzerland. | en_US |
Afiliación | Oswaldo Cruz Foundation. Institute Aggeu Magalhães. Department of Virology and Experimental Therapy. Recife, PE, Brazil. | en_US |
Afiliación | Ministry of Health. Department of HIV/AIDS, Tuberculosis, Viral Hepatitis and Sexually Transmitted Infections. Brasília, DF, Brazil. | en_US |
Afiliación | Ministry of Health. Department of HIV/AIDS, Tuberculosis, Viral Hepatitis and Sexually Transmitted Infections. Brasília, DF, Brazil. | en_US |
Afiliación | University of Brasilia. Department of Public Health. Brasília, DF, Brazil. | en_US |
Afiliación | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Emerging Infectious Diseases Branch. Walter Reed Army Institute of Research. Silver Spring, MD, USA. | en_US |
Afiliación | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Acute Febrile Illnesses Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
Afiliación | Department of Sexual and Reproductive Health and Research. World Health Organization. Geneva, Switzerland. | en_US |
Afiliación | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil. | en_US |
Palavras clave en Inglês | ZIKV rRT‑PCR detection | en_US |
Palavras clave en Inglês | ZIKV persistence in body fuids | en_US |
Palavras clave en Inglês | ZIKV RNA recurrent detection | en_US |
Palavras clave en Inglês | Factors associated with ZIKV persistence | en_US |
e-ISSN | 2045-2322 |
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