Author | Abreu-Fernandes, Rebecca de | |
Author | Almeida-de-Oliveira, Natália Ketrin | |
Author | Mello, Aline Rosa de Lavigne | |
Author | Queiroz, Lucas Tavares de | |
Author | Barros, Jacqueline de Aguiar | |
Author | Baptista, Bárbara de Oliveira | |
Author | Oliveira-Ferreira, Joseli | |
Author | Souza, Rodrigo Medeiros de | |
Author | Pratt-Riccio, Lilian Rose | |
Author | Brasil, Patrícia | |
Author | Daniel-Ribeiro, Cláudio Tadeu | |
Author | Ferreira-da-Cruz, Maria de Fátima | |
Access date | 2024-03-22T21:35:33Z | |
Available date | 2024-03-22T21:35:33Z | |
Document date | 2024 | |
Citation | ABREU-FERNANDES, Rebecca de et al. Are pvcrt-o and pvmdr1 Gene Mutations Associated with Plasmodium vivax Chloroquine-Resistant Parasites? Biomedicines, v. 12, n. 141, p. 1-12, Jan. 2024. | en_US |
ISSN | 2227-9059 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63174 | |
Description | Author Contributions: Conceptualization, M.d.F.F.-d.-C.; supervision, M.d.F.F.-d.-C.; methodology, R.d.A.-F., L.T.d.Q., A.R.d.L.M., B.d.O.B. and M.d.F.F.-d.-C.; epidemiological survey, J.O.-F., R.M.d.S., L.R.P.-R. and P.B.; formal analysis, R.d.A.-F., N.K.A.-d.-O., L.T.d.Q., J.d.A.B. and M.d.F.F.-d.-C.; Investigation, M.d.F.F.-d.-C. and C.T.D.-R.; resources, M.d.F.F.-d.-C.; original draft preparation, R.d.A.-F.; writing—review, M.d.F.F.-d.-C., C.T.D.-R., R.M.d.S., L.R.P.-R., J.O.-F. and P.B.; editing, R.d.A.-F.; project administration, M.d.F.F.-d.-C.; funding acquisition, M.d.F.F.-d.-C., C.T.D.-R. and P.B. All authors have read and agreed to the published version of the manuscript. | en_US |
Sponsorship | This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; http://www.cnpq.br/, accessed on 10 March 2022) through Research Productivity Fellowships to C.T.D.-R. (310445/2017-5), M.d.F.F.-d.-C. (306025/2018-3) and P.B. (311562/2021-3), who are also Cientistas do Nosso Estado (C.T.D.-R.—E-26/202.921/2018; M.d.F.F.-d.-C.—E26/203.295/2015 and P.B. E-26/200.925/2022) of the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado de Rio de Janeiro (FAPERJ; http://www.faperj.br/, accessed on 10 March 2022). This work was also supported by the Departamento de Ciência e Tecnologia em Saúde/Ministério da Saúde (DECIT/MS) (Grant No.: 402675/2018-5), Programa Nacional de Controle e Prevenção da Malária/Secretaria de Vigilância em Saúde/Ministério da Saúde (SVS/MS) and Fiocruz (Grant No.: 026-FIO-18-2-1). | en_US |
Language | eng | en_US |
Publisher | MDPI | en_US |
Rights | open access | en_US |
Title | Are pvcrt-o and pvmdr1 Gene Mutations Associated with Plasmodium vivax Chloroquine-Resistant Parasites? | en_US |
Type | Article | en_US |
DOI | 10.3390/biomedicines12010141 | |
Abstract | Background: Malaria remains a significant global public health issue. Since parasites quickly became resistant to most of the available antimalarial drugs, treatment effectiveness must be constantly monitored. In Brazil, up to 10% of cases of vivax malaria resistant to chloroquine (CQ) have been registered. Unlike P. falciparum, there are no definitive molecular markers for the chemoresistance of P. vivax to CQ. This work aimed to investigate whether polymorphisms in the pvcrt-o and pvmdr1 genes could be used as markers for assessing its resistance to CQ. Methods: A total of 130 samples from P. vivax malaria cases with no clinical and/or parasitological evidence of CQ resistance were studied through polymerase chain reaction for gene amplification followed by target DNA sequencing. Results: In the pvcrt-o exons, the K10 insert was present in 14% of the isolates. Regarding pvmdr1, T958M and F1076L haplotypes showed frequencies of 95% and 3%, respectively, while the SNP Y976F was not detected. Conclusions: Since K10-pvcrt-o and F1076L/T958M-pvmdr1 polymorphisms were detected in samples from patients who responded well to CQ treatment, it can be concluded that mutations in these genes do not seem to have a potential for association with the phenotype of CQ resistance. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Ministry of Health. Health Surveillance Secretariat. Oswaldo Cruz Foundation. Reference Laboratory for Malaria in the Extra-Amazonian Region for the Brazilian. Malaria Research, Diagnosis and Training Center. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Ministry of Health. Health Surveillance Secretariat. Oswaldo Cruz Foundation. Reference Laboratory for Malaria in the Extra-Amazonian Region for the Brazilian. Malaria Research, Diagnosis and Training Center. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Ministry of Health. Health Surveillance Secretariat. Oswaldo Cruz Foundation. Reference Laboratory for Malaria in the Extra-Amazonian Region for the Brazilian. Malaria Research, Diagnosis and Training Center. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Núcleo de Controle da Malária. Departamento de Vigilância Epidemiológica. Coordenação Geral de Vigilância em Saúde. Boa Vista, RR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Universidade Federal do Acre. Laboratório de Doenças Infecciosas da Amazônia Ocidental. Cruzeiro do Sul, AC, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Ministry of Health. Health Surveillance Secretariat. Oswaldo Cruz Foundation. Reference Laboratory for Malaria in the Extra-Amazonian Region for the Brazilian. Malaria Research, Diagnosis and Training Center. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Ministry of Health. Health Surveillance Secretariat. Oswaldo Cruz Foundation. Reference Laboratory for Malaria in the Extra-Amazonian Region for the Brazilian. Malaria Research, Diagnosis and Training Center. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Ministry of Health. Health Surveillance Secretariat. Oswaldo Cruz Foundation. Reference Laboratory for Malaria in the Extra-Amazonian Region for the Brazilian. Malaria Research, Diagnosis and Training Center. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Chloroquine | en_US |
Subject | Chemoresistance | en_US |
Subject | Malaria | en_US |
Subject | P. vivax | en_US |
Subject | pvcrt-o | en_US |
Subject | pvmdr1 | en_US |
e-ISSN | 2227-9059 | |