Author | Castilho, Marcia da Costa | |
Author | Filippis, Ana Maria Bispo de | |
Author | Machado, Lais Ceschini | |
Author | Calvanti, Thaise Yasmine Vasconcelos de Lima | |
Author | Lima, Morganna Costa | |
Author | Fonseca, Vagner | |
Author | Giovanetti, Marta | |
Author | Docena, Cassia | |
Author | Menezes Neto, Armando | |
Author | Bôtto-Menezes, Camila Helena Aguiar | |
Author | Kara, Edna Oliveira | |
Author | Barrera, Rafael de La | |
Author | Modjarrad, Kayvon | |
Author | Giozza, Silvana Pereira | |
Author | Pereira, Gerson Fernando | |
Author | Junior Alcantara, Luiz Carlos | |
Author | Broutet, Nathalie Jeanne Nicole | |
Author | Calvet, Guilherme Amaral | |
Author | Wallau, Gabriel Luz | |
Author | Franca, Rafael Freitas Oliveira | |
Access date | 2024-03-22T21:41:43Z | |
Available date | 2024-03-22T21:41:43Z | |
Document date | 2024 | |
Citation | CASTILHO, Marcia da Costa et al. Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil. Emerging Infectious Diseases, v. 30, n. 2, p. 310-320, Feb. 2024. | en_US |
ISSN | 1080-6040 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63175 | |
Description | Author contributions: A.M.B.F., M.G., V.F., L.C.J.A., L.C.M., and C.D. performed sequencing assays and data analysis, M.C.C., C.H.A.B.-M., and A.M-N. laboratory procedures and clinical data collection; G.A.C., E.K., and N.B. performed data analysis and clinical support; R.L.B. performed microneutralization assays, K.M. performed
study supervision and data analysis, G.L.W. performed phylogenetic analysis and manuscript editing, R.F.O.F. conceived and supervised the study and wrote the manuscript. All authors reviewed and approved the final version of the manuscript. The authors declare they have no conflict of interests, and the funders had no role in study design, data collection, analysis, decision to publish, or preparation of the manuscript. | en_US |
Language | eng | en_US |
Publisher | National Center for Infectious Diseases, Centers for Disease Control and Prevention | en_US |
Rights | open access | en_US |
Title | Evidence of Zika Virus Reinfection by Genome Diversity and Antibody Response Analysis, Brazil | en_US |
Type | Article | en_US |
DOI | 10.3201/eid3002.230122 | |
Abstract | We generated 238 Zika virus (ZIKV) genomes from 135 persons in Brazil who had samples collected over 1 year to evaluate virus persistence. Phylogenetic inference clustered the genomes together with previously reported ZIKV strains from northern Brazil, showing that ZIKV has been remained relatively stable over time. Temporal phylogenetic analysis revealed limited within-host diversity among most ZIKV-persistent infected associated samples. However, we detected unusual virus temporal diversity from >5 persons, uncovering the existence of divergent genomes within the same patient. All those patients showed an increase in neutralizing antibody levels, followed by a decline at the convalescent phase of ZIKV infection. Of interest, in 3 of those patients, titers of neutralizing antibodies increased again after 6 months of ZIKV infection, concomitantly with real-time reverse transcription PCR re-positivity, supporting ZIKV reinfection events. Altogether, our findings provide evidence for the existence of ZIKV reinfection events. | en_US |
Affilliation | Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Recife, PE, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute, Recife, PE, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Recife, PE, Brazil. | en_US |
Affilliation | Organização Mundial da Saúde. Organização Pan-Americana da Saúde. Brasília, DF, Brasil. | en_US |
Affilliation | University of Campus Bio-Medico di Roma. Rome, Italy. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Recife, PE, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Recife, PE, Brazil. | en_US |
Affilliation | Tropical Medicine Foundation Doctor Heitor Vieira Dourado. Manaus, AM, Brazil. | en_US |
Affilliation | World Health Organization. Geneva, Switzerland. | en_US |
Affilliation | Walter Reed Army Institute of Research. Silver Spring. Maryland, USA. | en_US |
Affilliation | Walter Reed Army Institute of Research. Silver Spring. Maryland, USA. | en_US |
Affilliation | Department of Chronic Condition Diseases and Sexually Transmitted Infections. Brasília, DF, Brazil. | en_US |
Affilliation | Department of Chronic Condition Diseases and Sexually Transmitted Infections. Brasília, DF, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Gonçalo Muniz Institute. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | World Health Organization. Geneva, Switzerland. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Research Laboratory in Acute Febrile Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Recife, PE, Brazil / National Reference Center for Tropical Infectious Diseases. Hamburg, Germany. | en_US |
Affilliation | Oswaldo Cruz Foundation. Aggeu Magalhães Institute, Virology and Experimental Therapy. Recife, PE, Brazil. | en_US |
Subject | Brazil | en_US |
Subject | Zika virus | en_US |
Subject | Epidemiology | en_US |
Subject | Evolution | en_US |
Subject | Genetic diversity | en_US |
Subject | Reinfection | en_US |
Subject | Vector-borne infections | en_US |
Subject | Viruses | en_US |
e-ISSN | 1080-6059 | |