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https://www.arca.fiocruz.br/handle/icict/63224
EXPLORING THE INTERPLAY BETWEEN COVID-19 AND GUT HEALTH: THE POTENTIAL ROLE OF PREBIOTICS AND PROBIOTICS IN IMMUNE SUPPORT
Author
Affilliation
Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma. Roma, Italy/Climate Amplified Diseases and Epidemics. Brasilia, DF, Brazil/Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma. Roma, Italy/Department of Agricultural. Enviromental and Food Science. University of Molise. Campobasso, Italy
Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma. Roma, Italy/Research Unit of Gastroenterology. Università Campus Bio-Medico di Roma. Rome, Italy
Research Unit of Gastroenterology. Università Campus Bio-Medico di Roma. Rome, Italy
Research Unit of Gastroenterology. Università Campus Bio-Medico di Roma. Rome, Italy/Operative Research Unit of Gastroenterology. Fondazione Policlinico Universitario Campus Bio-Medico. Rome, Italy
Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Roma, Italy
Unit of Virology. Fondazione Policlinico Universitario Campus Bio-Medico. Rome, Italy/Applied Bacteriological Sciences Unit. Department of Medicine and Surgery. Università Campus Bio-Medico di Roma. Rome, Italy
Applied Bacteriological Sciences Unit. Department of Medicine and Surgery. Università Campus Bio-Medico di Roma. Rome, Italy
Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma. Roma, Italy/Department of Agricultural. Enviromental and Food Science. University of Molise. Campobasso, Italy
Sciences and Technologies for Sustainable Development and One Health, Università Campus Bio-Medico di Roma. Roma, Italy/Research Unit of Gastroenterology. Università Campus Bio-Medico di Roma. Rome, Italy
Research Unit of Gastroenterology. Università Campus Bio-Medico di Roma. Rome, Italy
Research Unit of Gastroenterology. Università Campus Bio-Medico di Roma. Rome, Italy/Operative Research Unit of Gastroenterology. Fondazione Policlinico Universitario Campus Bio-Medico. Rome, Italy
Unit of Medical Statistics and Molecular Epidemiology. University Campus Bio-Medico of Rome. Roma, Italy
Unit of Virology. Fondazione Policlinico Universitario Campus Bio-Medico. Rome, Italy/Applied Bacteriological Sciences Unit. Department of Medicine and Surgery. Università Campus Bio-Medico di Roma. Rome, Italy
Applied Bacteriological Sciences Unit. Department of Medicine and Surgery. Università Campus Bio-Medico di Roma. Rome, Italy
Abstract
The COVID-19 pandemic has profoundly impacted global health, leading to extensive research focused on developing strategies to enhance outbreak response and mitigate the disease’s severity. In the aftermath of the pandemic, attention has shifted towards understanding and addressing long-term health implications, particularly in individuals experiencing persistent symptoms, known as long COVID. Research into potential interventions to alleviate long COVID symptoms has intensified, with a focus on strategies to support immune function and mitigate inflammation. One area of interest is the gut microbiota, which plays a crucial role in regulating immune responses and maintaining overall health. Prebiotics and probiotics, known for their ability to modulate the gut microbiota, have emerged as potential therapeutic agents in bolstering immune function and reducing inflammation. This review delves into the intricate relationship between long COVID, the gut microbiota, and immune function, with a specific focus on the role of prebiotics and probiotics. We examine the immune response to long COVID, emphasizing the importance of inflammation and immune regulation in the persistence of symptoms. The potential of probiotics in modulating immune responses, including their mechanisms in combating viral infections such as COVID-19, is discussed in detail. Clinical evidence supporting the use of probiotics in managing long COVID symptoms is summarized, highlighting their role as adjunctive therapy in addressing various aspects of SARS-CoV-2 infection and its aftermath.
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