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Autor | Freitas, Rafael Maciel de | |
Autor | Sauer, Felix G. | |
Autor | Kliemke, Konstantin | |
Autor | Garcia, Gabriela de Azambuja | |
Autor | Pavan, Márcio Galvão | |
Autor | David, Mariana Rocha | |
Autor | Schmidt-Chanasit, Jonas | |
Autor | Hoffmann, Ary | |
Autor | Lühken, Renke | |
Fecha de acceso | 2024-04-05T17:09:05Z | |
Fecha de disponibilización | 2024-04-05T17:09:05Z | |
Fecha de publicación | 2024 | |
Referencia | FREITAS, Rafael Maciel de et al. Wolbachia strains wMel and wAlbB differentially affect Aedes aegypti traits related to fecundity. Microbiology Spectrum, v. 12, n. 4, p. 1-20, 14 Mar. 2024. | en_US |
ISSN | 2165-0497 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63423 | |
Promoción | Deutsche Forschungsgemeinschaft (DFG), grant MA 9541/1-1, author Rafael Maciel-de-Freitas | |
Promoción | Bundesministerium für Bildung und Forschung (BMBF), grant NEED 01Kl2022, authors Felix G. Sauer, Konstantin Kliemke, Renke Lühken | |
Promoción | Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), grant E-14/2019, author Rafael Maciel-de-Freitas | |
Idioma | eng | en_US |
Editor | American Society for Microbiology | en_US |
Derechos de autor | open access | en_US |
Título | Wolbachia strains wMel and wAlbB differentially affect Aedes aegypti traits related to fecundity | en_US |
Tipo del documento | Article | en_US |
DOI | 10.1128/spectrum.00128-24 | |
Resumen en Inglés | Two Wolbachia strains, wMel and wAlbB, have been transinfected into Aedes aegypti mosquitoes for population replacement with the aim of reducing dengue transmission. Epidemiological data from various endemic sites suggest a pronounced decrease in dengue transmission after implementing this strategy. In this study, we investigated the impact of the Wolbachia strains wMel and wAlbB on Ae. aegypti fitness in a common genetic background. We found that Ae. aegypti females infected with the wMel strain exhibited several significant differences compared with those infected with the wAlbB strain. Specifically, wMel-infected females laid significantly fewer eggs, ingested a lower amount of blood, had a reduced egg production rate, and exhibited a decreased Wolbachia density at a later age compared with mosquitoes infected with the wAlbB strain. Conversely, the wAlbB strain showed only mild negative effects when compared with Wolbachia-uninfected specimens. These differential effects on Ae. aegypti fitness following infection with either wMel or wAlbB may have important implications for the success of population replacement strategies in invading native Ae. aegypti populations in endemic settings. Further research is needed to better understand the underlying mechanisms responsible for these differences in fitness effects and their potential impact on the long-term efficacy of Wolbachia-based dengue control programs. IMPORTANCE: The transmission of arboviruses such as dengue, Zika, and chikungunya is on the rise globally. Among the most promising strategies to reduce arbovirus burden is the release of one out of two strains of Wolbachia-infected Aedes aegypti: wMel and wAlbB. One critical aspect of whether this approach will succeed involves the fitness cost of either Wolbachia strains on mosquito life history traits. For instance, we found that wMel-infected Ae. aegypti females laid significantly fewer eggs, ingested a lower amount of blood, had a reduced egg production rate, and exhibited a decreased Wolbachia density at a later age compared with mosquitoes infected with the wAlbB strain. Conversely, the wAlbB strain showed only mild negative effects when compared with Wolbachia-uninfected specimens. These differential effects on mosquito fitness following infection with either wMel or wAlbB may have important implications for the success of population replacement strategies in invading native Ae. aegypti populations. | en_US |
Afiliación | Bernhard Nocht Institute for Tropical Medicine. Hamburg, Germany / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Bioquímica Médica Leopoldo de Meis. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil. | en_US |
Afiliación | Bernhard Nocht Institute for Tropical Medicine. Hamburg, Germany. | en_US |
Afiliación | Bernhard Nocht Institute for Tropical Medicine. Hamburg, Germany. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | en_US |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil. | en_US |
Afiliación | Bernhard Nocht Institute for Tropical Medicine. Hamburg, Germany / University of Hamburg. Faculty of Mathematics, Informatics and Natural Sciences. Hamburg, Germany. | en_US |
Afiliación | The University of Melbourne. Bio21 Institute. School of BioSciences. Pest and Environmental Adaptation Research Group. Melbourne, Australia. | en_US |
Afiliación | Bernhard Nocht Institute for Tropical Medicine. Hamburg, Germany. | en_US |
Palavras clave en Inglês | Aedes aegypti | en_US |
Palavras clave en Inglês | Wolbachia | en_US |
Palavras clave en Inglês | Vectorial capacity | en_US |
Palavras clave en Inglês | Disease transmission | en_US |
Palavras clave en Inglês | Blocking | en_US |
Palavras clave en Inglês | Life history traits | en_US |
e-ISSN | 2165-0497 |
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