Author | Calumby, Renata Freitas de A. T. | |
Author | Lima, Flávia Oliveira de | |
Author | Valasques Junior, Gildomar Lima | |
Author | Santos, Jener David Gonçalves | |
Author | Chaves, Pedro Felipe Pereira | |
Author | Cordeiro, Lucimara Mach Côrtes | |
Author | Villarreal, Cristiane Flora | |
Author | Soares, Milena Botelho Pereira | |
Author | Boffo, Elisangela Fabiana | |
Author | Assis, Sandra Aparecida de | |
Access date | 2024-04-08T18:03:28Z | |
Available date | 2024-04-08T18:03:28Z | |
Document date | 2023 | |
Citation | CALUMBY, Renata Freitas de A. T. et al. Antinociceptive and anti-inflammatory properties of α-D-mannan from the yeast Kluyveromyces marxianus: evidence for a role in interleukin-6 inhibition. Archives of Microbiology, v. 205, n. 379, p. 1-12, 2023. | en_US |
ISSN | 1432-072X | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63437 | |
Sponsorship | (Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES ).
Centro de RMN da UFPR, Programa de Pós-Graduação da UEFS em Biotecnologia. | en_US |
Language | eng | en_US |
Publisher | Springer | en_US |
Rights | open access | en_US |
Subject in Portuguese | Kluyveromyces marxianus | en_US |
Subject in Portuguese | Polissacarideo | en_US |
Subject in Portuguese | Atividade biológica | en_US |
Subject in Portuguese | Dor | en_US |
Subject in Portuguese | Inflamação | en_US |
Subject in Portuguese | Anti-inflamatório | en_US |
Title | Antinociceptive and anti‑inflammatory properties of α‑d‑mannan from the yeast Kluyveromyces marxianus: evidence for a role in interleukin‑6 inhibition | en_US |
Type | Article | en_US |
DOI | 10.1007/s00203-023-03718-2 | |
Abstract | The management of inflammatory states typically involves non-steroidal anti-inflammatory drugs (NSAIDs) and opiates. Understanding the mechanisms underlying the processing of nociceptive information from potential alternatives such as some polysaccharides may enable new and meaningful therapeutic approaches. In this study, α-D-mannan isolated from the Kluyveromyces marxianus cell wall produced antinociceptive effects in models of inflammatory pain (formalin and complete Freund’s adjuvant tests). Furthermore, α-D-mannan reduced paw edema and interleukin-6 (IL-6) production after carrageenan-induced inflammation. The polysaccharide α-D-mannan was characterized by gas chromatography–mass spectrometry, methylation analysis, and spectroscopic techniques. Moreover, the Doehlert experimental design was applied to find the optimal conditions for biomass production, with the best conditions being 10.8 g/L and 117 h for the glucose concentration and the fermentation time, respectively. These results indicate that α-D-mannan from K. marxianus exerts anti-inflammatory and antinociceptive effects in mice, possibly via a mechanism dependent on the inhibition of IL-6 production. | en_US |
Affilliation | Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil. | en_US |
Affilliation | Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil. | en_US |
Affilliation | Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil. | en_US |
Affilliation | Universidade Federal do Agreste de Pernambuco. Hospital Veterinário Universitário. Garanhuns, PE, Brasil. | en_US |
Affilliation | Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil | en_US |
Affilliation | Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Federal da Bahia. Instituto de Química. Salvador, BA, Brasil. | en_US |
Affilliation | Universidade Estadual de Feira de Santana. Departamento de Saúde. Feira de Santana, BA, Brasil. | en_US |
Subject | Kluyveromyces marxianus | en_US |
Subject | Polysaccharide | en_US |
Subject | Biological activity | en_US |
Subject | Pain | en_US |
Subject | Inflammation | en_US |
Subject | Anti-inflammatory | en_US |
DeCS | Polissacarídeos | en_US |
DeCS | Dor | en_US |
DeCS | Inflamação | en_US |
DeCS | Anti-inflamatório | en_US |