| Author | Elsas, Maria Ignez Capella Gaspar | |
| Author | Maximiniano, Elisabeth S. | |
| Author | Joseph, Danielle | |
| Author | Alves, Letícia | |
| Author | Topilko, Andrzej | |
| Author | Vargaftig, B. Boris | |
| Author | Xavier-Elsas, Pedro Paulo | |
| Access date | 2013-03-11T14:29:27Z | |
| Available date | 2013-03-11T14:29:27Z | |
| Document date | 2000 | |
| Citation | ELSAS, Maria Ignez Capella Gaspar et al. Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice. British Journal of Pharmacology, London, v. 129, n. 8, p. 1543-1552, Apr. 2000. | pt_BR |
| ISSN | 1365-2125 | |
| URI | https://www.arca.fiocruz.br/handle/icict/6362 | |
| Sponsorship | PAPES/FIOCRUZ, FINEP, CNPq/RHAE,INSERM/FIOCRUZ, CAPES-COFECUB Institut Pasteur/INSERM | pt_BR |
| Language | eng | pt_BR |
| Publisher | Blackwell Scientific Publications | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | AGARWAL, S.K. &MARSHALL, G.D. (1998). Glucocorticoid-induced
Type 1/Type 2 cytokine alterations in humans: a model for stress-
related immune dysfunction. J. Interferon Cytokine Res., 18,
1059 - 1068. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | BAGBY, G.C. (1994). Hematopoiesis. In: Stamatoyannopoulos, G.,
Nienhuis, A.W.,Majerus, P.W., Varmus H. (eds.), TheMolecular
Basis of Blood Diseases (2nd. Ed.), W.B. Saunders, Philadelphia,
pp. 71 - 106. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | BARNES, P.J. (1996). Molecular mechanisms of steroid action in
asthma. J. Allergy Clin. Immunol., 97, 159 - 168. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | BARR, D.D., VOLARIC, Z. & KLIM, J.B. (1987). Stimulation of human
eosinophilopoiesis by hydrocortisone in vitro. Acta Haematol.,
77, 20 - 24. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | BEGLEY, C.G., BASSER, R., MANSFIELD, R., THOMSON, B.,
PARKER, W.R.L., LAYTON, J., TO, B., CEBON, J., SHERIDAN,
W.P., FOX, R.M. & GREEN, M.D. (1997). Enhanced levels and
enhanced clonogenic capacity of blood progenitor cells following
administration of stem cell factor plus granulocyte colony
stimulating factor to humans. Blood, 90, 3378 - 3389. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | BUTTERFIELD, J.H., ACKERMAN, S.J., WEILER, D., EISENBREY,
A.B. & GLEICH, G.J. (1986). E ects of glucocorticoids on
eosinophil colony growth. J. Allergy Clin. Immunol., 78, 450 -
457. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | CLUTTERBUCK, E.J., HIRST, E.M.A. & SANDERSON, C.J. (1989).
Human Interleukin-5 (IL-5) regulates the production of
eosinophils in human bone marrow cultures: comparison and
interaction with IL-1, IL-3, IL-6, and GM-CSF. Blood, 73,
1504 - 1512. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | DAS, A.M., FLOWER, R.J., HELLEWELL, P.G., TEIXEIRA, M. &
PERRETTI, M. (1997). A novel murine model of allergic
in¯ammation to study the e ect of Dexamethasone on eosinophil
recruitment. Br. J. Pharmacol., 121, 97 - 104. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | EGESTEN, A., CALAFAT, J.,WELLER, P.F., KNOL, E.F., JANSSEN, H.,
WALZ, T.M. & OLSSON, I. (1997). Localization of granule proteins
in human eosinophil bone marrow progenitors. Int. Arch. Allergy
Immunol., 114, 130 - 138. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | EUM, S.Y., HAILEÂ , S., LEFORT, J., HUERRE, M. & VARGAFTIG, B.B.
(1995). Eosinophil recruitment into the respiratory epithelium
following antigenic challenge in hyper-IgE mice is accompanied
by interleukin-5-dependent bronchial hyperresponsiveness. Proc.
Natl. Acad. Sci. U.S.A., 92, 12290 - 12294. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | GASPAR ELSAS,M.I., JOSEPH, D., XAVIER ELSAS, P. & VARGAFTIG,
B.B. (1997). Rapid increase in bone marrow eosinophil produc-
tion and responses to eosinopoietic interleukins triggered by
intranasal allergen challenge. Amer. J. Resp. Cell. Mol. Biol., 17,
404 - 413. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | GIEMBYCZ, M.A. & LINDSAY, M.A. (1999). Pharmacology of the
Eosinophil. Pharmacol. Rev., 51, 213 - 339. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | GRUART, V., TRUONG, M.-J., PLUMAS, J., ZANDECKI, M., KUS-
NIERZ, J.-P., PRIN, L., VINATIER, D., CAPRON, A. & CAPRON, M.
(1992). Decreased expression of eosinophil peroxidase and major
basic protein messenger RNAs during eosinophil maturation.
Blood, 79, 2592 - 2597. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | HALL, T.L. & FU, Y.S. (1985). Applications of quantitative
microscopy to tumor pathology. Lab. Invest., 53, 5 - 21. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | HARDY, E., FARAHANI, M. & HALL, I.P. (1996). Regulation of
histamine H1 receptor coupling by dexamethasone in human
cultured airway smooth muscle. Br. J. Pharmacol., 118, 1079 -
1084. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | HER, E., FRAZER, J., AUSTEN, K.F. & OWEN,W.F. (1991). Eosinophil
hematopoietins antagonize the programmed cell death of
eosinophils. Cytokine and glucocorticoid e ects on eosinophils
maintained by endothelial cell-conditioned medium. J. Clin.
Invest., 88, 1982 - 1987. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | HISHA, H., YAMADA, H., SAKURAI, M.H., KIYOHARA, H., LI, Y.,
YU, C., TAKEMOTO, N., KAWAMURA, H., YAMAURA, K.,
SHINOHARA, S., KOMATSU, Y., ABURADA, M. & IKEHARA, S.
(1997). Isolation and identi®cation of hematopoietic stem cell-
stimulating substances from Kampo (japanese herbal) medicine,
Juzen-Taiho-To. Blood, 90, 1022 - 1030. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | HORTON, M.A., LARSON, K.A., LEE, J.J. & LEE, N.A. (1996). Cloning
of the murine eosinophil peroxidase gene (mEPO): characteriza-
tion of a conserved subgroup of mammalian hematopoietic
peroxidases. J. Leukocyte Biol., 60, 285 -294. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | INMAN, M.D., DENBURG, J.A., ELLIS, R., DAHLBAÈ
CK, M. &
O'BYRNE, P.M. (1997). The e ect of treatment with budesonide
or PGE2 in vitro on allergen-induced increases in canine bone
marrow progenitors. Am. J. Respir. Cell. Mol. Biol., 17, 634 -
661. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | JOHNSON, G.R. (1984). Haemopoietic multipotential stem cells in
culture. Clinics in Haematology, 13, 309 - 327. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | KATAYAMA, I., IGAWA, K., MINATOHARA, K. & NISHIOKA, K.
(1997). Topical glucocorticoid augments IgE-mediated passive
cutaneous anaphylaxis in Balb/C mice and mast cell deficient
WBB6F1 v/v mice. Clin. Exp. Allergy, 27, 1477 -1483. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | KUNICKA, J.E., TALLE, M.A., DENHARDT, G.H., BROWN, M.,
PRINCE, L.A. & GOLDSTEIN, G. (1993). Immunosuppression by
glucocorticoids: inhibition of production of multiple lympho-
kines by in vivo administration of dexamethasone. Cell.
Immunol., 149, 39 - 49. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | LEFORT, J., BACHELET, C.M., LEDUC, D & VARGAFTIG, B.B. (1996).
E ect of antigen provocation of IL-5 transgenic mice on
eosinophil mobilization and bronchial hyperresponsiveness. J.
Allergy Clin. Immunol., 97, 788 - 799. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | MARUYAMA, S., MINAGAWA, M., SHIMIZU, T., OYA, H., YAMA-
MOTO, S., MUSHA, N., ABO, W., WEERASINGHE, A., HATA-
KEYAMA, K. & ABO, T. (1999). Administration of glucocorticoids
markedly increases the numbers of granulocytes and extrathymic
T cells in the bone marrow. Cell. Immunol., 194, 28 - 35. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | METCALF, D. (1998). Lineage commitment in the progeny of murine
hematopoietic preprogenitor cells: in¯uence of thrombopoietin
and Interleukin-5. Proc. Natl. Acad. Sci. U.S.A., 95, 6408 - 6412. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | MICHEL, F.B. (1994). Psychology of the allergic patient. Allergy, 49,
28 - 30. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | MITA, S., TAKAKI, S., TOMINAGA, A. & TAKATSU, K. (1993).
Comparative analysis of the kinetics of binding and internaliza-
tion of IL-5 in murine IL-5 receptors of high and low a nity. J.
Immunol., 151, 6924 - 6932. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | OSKERITZIAN, C., LE MAO, J. & DAVID, B. (1998). Recombinant
murine (rm) interleukin-5 enhances the eosinophil peroxidase
content in cells cultured in vitro compared with rmIL-3 and
granulocyte-macrophage colony-stimulating factor. Exp. Hema-
tol., 26, 472 - 477. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | PARKER, C.W. (1991). Environmental stress and immunity: possible
implications for IgE-mediated allergy. Perspect. Biol. Med., 34,
197 - 212. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | PERRETTI, M. & FLOWER, R.J. (1996). Measurement of lipocortin 1
levels in murine peripheral blood leukocytes by ¯ow cytometry:
modulation by glucocorticoids and in¯ammation. Br. J.
Pharmacol., 118, 605 - 610. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | POZZULO, G.N., SKAMENE, E. & GERVAIS, F. (1993). Bone marrow
cell response following induction of acute in¯ammation in
di erent strains of mice. Inammation, 17, 677 - 685. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | RINEHART, J., KEVILLE, L., CLAYTON, S. & FIGUEROA, J.A. (1997).
Corticosteroids alter hematopoiesis in vitro by enhancing human
monocyte secretion of granulocyte colony-stimulating factor.
Exp. Hematol., 25, 405 - 412. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | ROBERTS, A.W., FOOTE, S., ALEXANDER, W.S., SCOTT, C., ROBB, L.
& METCALF, D. (1997). Genetic in¯uences determining progeni-
tor cell mobilization and leukocytosis induced by granulocyte
colony-stimulating factor. Blood, 89, 2736 - 2744. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | SANDERSON, C.J. (1992). Interleukin-5, eosinophils and disease.
Blood, 79, 3101 - 3109. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | SCHLEIMER, R.P. & BOCHNER, B.S. (1994). The e ects of
glucocorticoids on human eosinophils. J. Allergy Clin. Immunol.,
94, 1202 - 1213. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | SCHIBLER, K.R., LI, Y., OHLS, R.K., NYE, N.C., DURHAM, M.C.,
WHITE,W., LIECHTY, K.W., LE, T. & CHRISTENSEN, R.D. (1994).
Possible mechanisms accounting for the growth factor indepen-
dence of hematopoietic progenitors from umbilical cord blood.
Blood, 84, 3679 - 3684. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | SHALIT, M., SEKHSARIA, S. & MALECH, H.L. (1995). Modulation of
growth and di erentiation of eosinophils from human peripheral
blood CD34+ cells by IL5 and other growth factors. Cell.
Immunol., 160, 50 - 57. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | SLOVICK, F.T., ABBOUD, C.N., BRENNAN, J.K. & LICHTMAN, M.A.
(1985). Modulation of in vitro eosinophil progenitors by
hydrocortisone: role of accessory cells and interleukins. Blood,
66, 1072 - 1079. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | STRATH, M., WARREN, D. & SANDERSON, C.J. (1985). Detection of
eosinophils using an EPO assay. Its use as an assay for eosinophil
di erentiation factors. J. Immunol. Methods, 83, 209 - 215. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | TEN, R.M., PEASE, L.R., MCKEAN, D.J., BELL, M.P. & GLEICH, G.J.
(1989). Molecular cloning of human eosinophil peroxidase.
evidence for the existence of a peroxidase multigene family. J.
Exp. Med., 169, 1757 - 1769. | pt_BR |
| xmlui.metadata.dc.relation.isbasedon | WILCKENS, T. & DE RIJK, R. (1997). Glucocorticoids and immune
functions: unknown dimensions and new frontiers. Immunol.
Today, 18, 418 - 424. | pt_BR |
| Rights | open access | pt_BR |
| Title | Upregulation by glucocorticoids of responses to eosinopoietic cytokines in bone-marrow from normal and allergic mice | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1038/sj.bjp.0703145 | |
| Abstract | Since the production of eosinopoietic cytokines (GM-CSF, IL-3, IL-5) is inhibited by glucocorticoids, while responsiveness to these cytokines is enhanced in bone-marrow of allergic mice, we studied the ability of glucocorticoids to modulate murine bone-marrow eosinopoiesis. Progenitor (semi-solid) and/or precursor (liquid) cultures were established from bone-marrow of: (a) normal mice; (b) ovalbumin-sensitized and challenged mice or (c) dexamethasone (1-5 mg kg(-1)) injected mice. Cultures were established with GM-CSF (2 ng ml(-1)) or IL-5 (1 ng ml(-1)), respectively, alone or associated with dexamethasone, hydrocortisone or corticosterone. Total myeloid colony numbers, frequency and size of eosinophil colonies, and numbers of eosinophil-peroxidase-positive cells were determined at day 7. In BALB/c mice, dexamethasone (10(-7) M) increased GM-CSF-stimulated myeloid colony formation (P = 0.01), as well as the frequency (P=0.01) and size (P<0.01) of eosinophil colonies. Dexamethasone (10(-7) M) alone had no effect. Dexamethasone (10(-7)-10(-10) M) increased (P<0.002) eosinophil precursor responses to IL-5. Potentiation by dexamethasone was still detectable: (a) on low density, immature, nonadherent BALB/c bone-marrow cells, (b) on bone-marrow from other strains, and (c) on cells from allergic mice. Hydrocortisone and corticosterone had similar effects. Dexamethasone administered in vivo, 24 h before bone-marrow harvest, increased subsequent progenitor responses to GM-CSF (P = 0.001) and precursor responses to IL-5 (P<0.001). These effects were blocked by RU 486 (20 mg kg(-1), orally, 2 h before dexamethasone, or added in vitro at 10 microM, P<0.001). Glucocorticoids, acting in vivo or in vitro, through glucocorticoid receptors, enhance bone-marrow eosinopoiesis in naïve and allergic mice. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pesquisa. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | INSERM. Unité Associeé Institut Pasteur. Uniteé de Pharmacologie Cellulaire. Paris, France. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Institut Pasteur. Station Centrale de Microscopie Électronique. Paris, France. | pt_BR |
| Affilliation | INSERM. Unité Associeé Institut Pasteur. Uniteé de Pharmacologie Cellulaire. Paris, France. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Glucocorticoids | pt_BR |
| Subject | Eosinophil | pt_BR |
| Subject | GM-CSF | pt_BR |
| Subject | IL-5 | pt_BR |
| Subject | Bone-marrow | pt_BR |
| DeCS | Citocinas | pt_BR |
| DeCS | Glucocorticóides | pt_BR |
| DeCS | Hipersensibilidade | pt_BR |
| DeCS | Receptores de Glucocorticóides | pt_BR |
