Author | Vieira, Marcelo Carvalho | |
Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
Author | Silva, Paula Simplicio da | |
Author | Sperandio da Silva, Gilberto Marcelo | |
Author | Mazzoli-Rocha, Flavia | |
Author | Sousa, Andrea Silvestre de | |
Author | Saraiva, Roberto Magalhaes | |
Author | Holanda, Marcelo Teixeira de | |
Author | Kasal, Daniel Arthur Barata | |
Author | Costa, Henrique Silveira | |
Author | Borges, Juliana Pereira | |
Author | Reis, Michel Silva | |
Author | Rodrigues Junior, Luiz Fernando | |
Author | Hasslocher-Moreno, Alejandro Marcel | |
Author | Brasil, Pedro Emmanuel Alvarenga Americano do | |
Author | Mediano, Mauro Felippe Felix | |
Access date | 2024-04-25T23:55:40Z | |
Available date | 2024-04-25T23:55:40Z | |
Document date | 2024 | |
Citation | VIEIRA, Marcelo Carvalho et al. Efect of an exercise‑based cardiac rehabilitation program on quality of life of patients with chronic Chagas cardiomyopathy: results from the PEACH randomized clinical trial. Scientific Reports, v. 14, n. 8208, p. 1-10, Apr. 2024. | en_US |
ISSN | 2045-2322 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63705 | |
Sponsorship | Te authors declare that no funds, grants, or other support were received during the preparation of this manuscript. | en_US |
Language | eng | en_US |
Publisher | Nature Portfolio | en_US |
Rights | open access | en_US |
Title | Effect of an exercise‑based cardiac rehabilitation program on quality of life of patients with chronic Chagas cardiomyopathy: results from the PEACH randomized clinical trial | en_US |
Type | Article | en_US |
DOI | 10.1038/s41598-024-58776-3 | |
Abstract | To investigate the effect of an exercise-based cardiac rehabilitation program on the quality of life (QoL) of patients with chronic Chagas cardiomyopathy (CCC). PEACH study was a single-center, superiority randomized clinical trial of exercise training versus no exercise (control). The sample comprised Chagas disease patients with CCC, left ventricular ejection fraction < 45%, without or with HF symptoms (CCC stages B2 or C, respectively). QoL was assessed at baseline, after three months, and at the end of six months of follow-up using the SF-36 questionnaire. Patients randomized for the exercise group (n = 15) performed exercise training (aerobic, strength and stretching exercises) for 60 min, three times a week, during six months. Patients in the control group (n = 15) were not provided with a formal exercise prescription. Both groups received identical nutritional and pharmaceutical counseling during the study. Longitudinal analysis of the effects of exercise training on QoL, considering the interaction term (group × time) to estimate the rate of changes between groups in the outcomes (represented as beta coefficient), was performed using linear mixed models. Models were fitted adjusting for each respective baseline QoL value. There were significant improvements in physical functioning (β = + 10.7; p = 0.02), role limitations due to physical problems (β = + 25.0; p = 0.01), and social functioning (β = + 19.2; p < 0.01) scales during the first three months in the exercise compared to the control group. No significant differences were observed between groups after six months. Exercise-based cardiac rehabilitation provided short-term improvements in the physical and mental aspects of QoL of patients with CCC. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil / Aloysio de Castro State Institute of Cardiology. Center for Cardiology and Exercise. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil / State University of Rio de Janeiro. Internal Medicine Department. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Jequitinhonha and Mucuri Valleys. Department of Physical Therapy. Diamantina, MG, Brazil. | en_US |
Affilliation | University of Rio de Janeiro State. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Federal University of Rio de Janeiro. Faculty of Physical Therapy. School of Medicine. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil / Federal University of the State of Rio de Janeiro. Department of Physiological Sciences. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Disease. Rio de Janeiro, RJ, Brazil / National Institute of Cardiology. Department of Research and Education. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | Cardiac rehabilitation | en_US |
Subject | Chagas cardiomyopathy | en_US |
Subject | Neglected diseases | en_US |
Subject | Exercise | en_US |
Subject | Heart failure | en_US |
Subject | Quality of life | en_US |
e-ISSN | 2045-2322 | |