Author | Arantes, Ighor | |
Author | Gomes, Marcelo | |
Author | Ito, Kimihito | |
Author | Sarafim, Sharbilla | |
Author | Miyajima, Fábio | |
Author | Khouri, Ricardo | |
Author | Gräf, Tiago | |
Author | Siqueira, Marilda Mendonça | |
Author | Resende, Paola Cristina | |
Author | Naveca, Felipe Gomes | |
Author | Bello, Gonzalo | |
Access date | 2024-05-02T13:21:32Z | |
Available date | 2024-05-02T13:21:32Z | |
Document date | 2023-10-31 | |
Citation | ARANTES, Ighor et al. Spatiotemporal dynamics and epidemiological impact of SARS-CoV-2 XBB lineages dissemination in Brazil in 2023. Microbiology Spectrum, p. 1-24, 2023. | en_US |
ISSN | 2165-0497 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/63811 | |
Sponsorship | Fundação de Amparo a Pesquisa do Estado do Amazonas (FAPEAM).
Rede Genômica de Vigilância em Saúde (REGESAM).
Programa Inova Fiocruz – Inovação na Amazônia.
U.S. Agency for International Development (USAID).
Centers for Disease Control and Prevention.
Ministério da Saúde; Departamento de Ciência e Tecnologia (DECIT).
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). | en_US |
Language | eng | en_US |
Publisher | American Society for Microbiology | en_US |
Rights | open access | en_US |
Subject in Portuguese | SARS-CoV-2 | en_US |
Subject in Portuguese | Epidemiológico | en_US |
Subject in Portuguese | Disseminação de linhagens | en_US |
Subject in Portuguese | Brasil | en_US |
Title | Spatiotemporal dynamics and epidemiological impact of SARS-CoV-2 XBB lineages dissemination in Brazil in 2023 | en_US |
Type | Article | en_US |
DOI | 10.1101/2023.10.30.23297466 | |
Abstract | The SARS-CoV-2 XBB is a group of highly immune-evasive lineages of the Omicron VOC that emerged by recombining BA.2-descendent lineages and spread worldwide during 2023. In this study, we combine SARS-CoV-2 genomic data (n = 11,065 sequences) with epidemiological data of Severe Acute Respiratory Infection (SARI) cases collected in Brazil between October 2022 and July 2023 to reconstruct the space-time dynamics and epidemiologic impact of XBB dissemination in the country. Our analyses revealed that the introduction and local emergence of lineages carrying convergent mutations within the Spike protein, especially F486P, F456L, and L455F, propelled the spread of XBB* lineages in Brazil. The average relative instantaneous reproduction numbers of XBB*+F486P, XBB*+F486P+F456L, and XBB*+F486P+ F456L+L455F lineages in Brazil were estimated to be 1.24, 1.33, and 1.48 higher than that of other co-circulating lineages (mainly BQ.1*/BE*), respectively. Despite such a growth advantage, the dissemination of these XBB* lineages had a reduced impact on Brazil’s epidemiological scenario concerning previous Omicron subvariants. The peak number of SARI cases from SARS-CoV-2 during the XBB wave was approximately 90%, 80%, and 70% lower than that observed during the previous BA.1*, BA.5*, and BQ.1* waves, respectively. These findings revealed the emergence of multiple XBB lineages with progressively increasing growth advantage, yet with relatively limited epidemiological impact in Brazil throughout 2023. The XBB*+F486P+F456L+L455F lineages stand out for their heightened transmissibility, warranting close monitoring in the months ahead. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, Fiocruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Grupo de Métodos Analíticos em Vigilância Epidemiológica. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | International Institute for Zoonosis Control. Hokkaido University. Hokkaido, Japan. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, Fiocruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Fortaleza, CE, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências Virais. Rio de Janeiro, RJ, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, Fiocruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Núcleo de Vigilância de Vírus Emergentes, Reemergentes ou Negligenciados. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, Fiocruz. Laboratório de Arbovírus e Vírus Hemorrágicos. Rio de Janeiro, RJ, Brasil. | en_US |
Subject | SARS-CoV-2 | en_US |
Subject | Epidemiological | en_US |
Subject | Lineages dissemination | en_US |
Subject | Brazil | en_US |
DeCS | SARS-CoV-2 | en_US |
DeCS | Epidemiologia | en_US |
DeCS | Transmissão de doença infecciosa | en_US |
DeCS | Brasil | en_US |