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https://www.arca.fiocruz.br/handle/icict/63826
FEEDBACK-LOOP BETWEEN PSYCHOTIC SYMPTOMS AND BRAIN VOLUME: A CROSS-LAGGED PANEL MODEL STUDY
Autor(es)
Afiliação
Virginia Institute for Psychiatric and Behavioral Genetics. Virginia Commonwealth University. Richmond, VA, USA / Deptartment of Psychiatry. The University of Melbourne. Austin Health, Victoria, Australia
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde (CIDACS). Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde (CIDACS). Salvador, BA, Brasil.
Deptartment of Psychiatry. The University of Melbourne. Austin Health, Victoria, Australia
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde (CIDACS). Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para Saúde (CIDACS). Salvador, BA, Brasil.
Deptartment of Psychiatry. The University of Melbourne. Austin Health, Victoria, Australia
Resumo em Inglês
Brain structural changes are known to be associated with psychotic symptoms, with worse symptoms consistently associated with brain volume loss in some areas. It is not clear whether volume and symptoms interfere with each other over the course of psychosis. In this paper, we analyse the temporal relationships between psychosis symptom severity and total gray matter volume. We applied a cross-lagged panel model to a public dataset from the NUSDAST cohorts. The subjects were assessed at three-time points: baseline, 24 months, and 48 months. Psychosis symptoms were measured by SANS and SAPS scores. The cohort contained 673 subjects with schizophrenia, healthy subjects and their siblings. There were significant effects of symptom severity on total gray matter volume and vice-versa. The worse the psychotic symptoms, the smaller the total gray volume, and the smaller the volume, the worse the symptomatology. There is a bidirectional temporal relationship between symptoms of psychosis and brain volume.
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