Author | Kasahara, Taissa M. | |
Author | Hygino, Joana | |
Author | Blanco, Bernardo | |
Author | Xavier, Luciana | |
Author | Lima, Carlos Fernando Araújo | |
Author | Guillermo, Landi V. C. | |
Author | Bittencourt, Vera Carolina B. | |
Author | Guimarães, Vander | |
Author | Andrade, Arnaldo F. B. | |
Author | Bento, Cleonice A. M. | |
Access date | 2013-08-13T17:38:43Z | |
Available date | 2013-08-13T17:38:43Z | |
Document date | 2013 | |
Citation | KASAHARA, Taissa M. The impact of maternal anti-retroviral therapy on cytokine profile in the uninfected neonates. Hum Immunol., New York, v. 74, n. 9, p. 1051-1056, set. 2013. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/6787 | |
Sponsorship | FAPERJ, CNPq, CAPES | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier / North-Holland | pt_BR |
Rights | restricted access | pt_BR |
Title | The impact of maternal anti-retroviral therapy on cytokine profile in the uninfected neonates | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.humimm.2013.06.010 | |
Abstract | The number of HIV-infected young women has been increasing since the beginning of the AIDS epidemic. The objective of the present study was to investigate the impact of anti-retroviral treatment (ART) of HIV-1-infected pregnant women (PW) on cytokine profile of uninfected neonates. Our results demonstrated that higher levels of IL-1β and TNF-α associated with lower IL-10 production were detected in the plasma obtained from neonates born from ART-treated PW. Furthermore, the production of TNF- α and IFN-γ was also significantly higher in polyclonally-activated T cells from those neonates. This elevated pro-inflammatory pattern detected by these activated-T cells was not associated to HIV-1 antigens sensitization. Finally, ART-exposed neonates showed to be born with lower weight, and it was inversely correlated with maternal peripheral TNF-a level. In summary, the data presented here suggest a significant disturbance in cytokine network of HIV-1-uninfected neonates exposed to potent anti-retroviral schemes during pregnancy. | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal do Estado do Rio de Janeiro. Departamento de Microbiologia e Parasitologia. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Departamento de Microbiologia, Parasitologia e Imunologia. Rio de Janeiro, RJ, Brasil | pt_BR |
DeCS | Gravidez | pt_BR |
DeCS | HIV-1 | pt_BR |
DeCS | Citocinas | pt_BR |
DeCS | Antirretrovirais | pt_BR |