Author | Silva, Maria Luiza | |
Author | Santo, Luçandra Ramos Espírito | |
Author | Martins, Marina Angela | |
Author | Lemos, Denise da Silveira | |
Author | Pascoal, Vanessa Peruhype Magalhães | |
Author | Caminha, Ricardo Carvalho | |
Author | Maranhão Filho, Péricles de Andrade | |
Author | Martins, Maria Auxiliadora | |
Author | Martins, Reinaldo de Menezes | |
Author | Galler, Ricardo | |
Author | Freire, Marcos da Silva | |
Author | Marcovistz, Rugimar | |
Author | Homma, Akira | |
Author | Teuwen, Dirk E. | |
Author | Santos, Silvana Maria Elói | |
Author | Andrade, Mariléia Chaves de | |
Author | Carvalho, Andréa Teixeira de | |
Author | Martins Filho, Olindo Assis | |
Access date | 2013-09-30T17:55:21Z | |
Available date | 2013-09-30T17:55:21Z | |
Document date | 2010 | |
Citation | SILVA, Maria Luiza et al. Clinical and immunological insights on severe, adverse neurotropic and viscerotropic disease following 17D yellow fever vaccination. Clin Vaccine Immunol. 2010 Jan;17(1):118-26. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/7019 | |
Language | eng | pt_BR |
Rights | restricted access | |
Rights | restricted access | pt_BR |
Title | Clinical and immunological insights on severe, adverse neurotropic and viscerotropic disease following 17D yellow fever vaccination | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/CVI.00369-09 | |
Abstract | Yellow fever (YF) vaccines (17D-204 and 17DD) are well tolerated and cause very low rates of severe adverse events (YEL-SAE), such as serious allergic reactions, neurotropic adverse diseases (YEL-AND), and viscerotropic diseases (YEL-AVD). Viral and host factors have been postulated to explain the basis of YEL-SAE. However, the mechanisms underlying the occurrence of YEL-SAE remain unknown. The present report provides a detailed immunological analysis of a 23-year-old female patient. The patient developed a suspected case of severe YEL-AVD with encephalitis, as well as with pancreatitis and myositis, following receipt of a 17D-204 YF vaccination. The patient exhibited a decreased level of expression of Fc-gammaR in monocytes (CD16, CD32, and CD64), along with increased levels of NK T cells (an increased CD3(+) CD16(+/-) CD56(+/-)/CD3(+) ratio), activated T cells (CD4(+) and CD8(+) cells), and B lymphocytes. Enhanced levels of plasmatic cytokines (interleukin-6 [IL-6], IL-17, IL-4, IL-5, and IL-10) as well as an exacerbated ex vivo intracytoplasmic cytokine pattern, mainly observed within NK cells (gamma interferon positive [IFN-gamma(+)], tumor necrosis factor alpha positive [TNF-alpha(+)], and IL-4 positive [IL-4(+)]), CD8(+) T cells (IL-4(+) and IL-5(+)), and B lymphocytes (TNF-alpha(+), IL-4(+), and IL-10(+)). The analysis of CD4(+) T cells revealed a complex profile that consisted of an increased frequency of IL-12(+) and IFN-gamma(+) cells and a decreased percentage of TNF-alpha(+), IL-4(+), and IL-5(+) cells. Depressed cytokine synthesis was observed in monocytes (TNF-alpha(+)) following the provision of antigenic stimuli in vitro. These results support the hypothesis that a strong adaptive response and abnormalities in the innate immune system may be involved in the establishment of YEL-AND and YEL-AVD. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil/ Universidade Estadual de Montes Claros. Montes Claros, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil/ Universidade Federal de Ouro Preto. Nucleo de Pos-graduação em Ciencias Biologicas. Ouro Preto, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil/Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Pesquisa Clínicas. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitario. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitario. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Hospital das Clínicas. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiologicos-Biomanguinhos. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiologicos-Biomanguinhos. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiologicos-Biomanguinhos. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiologicos-Biomanguinhos. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiologicos-Biomanguinhos. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Catholic University of Leuven. Rega Institute. Leuven, Belgium | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Propedeutica Clínica. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil/ Universidade Estadual de Montes Claros. Montes Claros, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores de Diagnostico e Monitoração. Belo Horizonte, MG, Brazil/University of Texas Medical Branch. International Laboratory Network for Yellow Fever Vaccine Associated Adverse Events. Sealy Center for Vaccine Development. Galveston, TX, USA | pt_BR |
Subject | Cytokines/blood | pt_BR |
Subject | Encephalitis/chemically induced | pt_BR |
Subject | Encephalitis/pathology | pt_BR |
Subject | Myositis/complications | pt_BR |
Subject | T-Lymphocytes/chemistry | pt_BR |
Subject | T-Lymphocytes/immunology | pt_BR |