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https://www.arca.fiocruz.br/handle/icict/7091
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ArtigoDireito Autoral
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- IFF - Artigos de Periódicos [1265]
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ANTIMICROBIAL SUSCEPTIBILITY AND GENETIC DIVERSITY OF STREPTOCOCCUS AGALACTIAE RECOVERED FROM NEWBORNS AND PREGNANT WOMEN IN BRAZIL
Antimicrobial Resistance
Genetic Diversity
Virulence Factors
Capsular Typing
Anti-Infecciosos - análise
Variação Genética
Fatores de Virulência - análise
Autor(es)
Afiliação
Universidade Federal Fluminense. Instituto Biomédico. Departamento Microbiologia e Parasitologia. Niterói, RJ, Brasil. / Fleury Group, Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fleury Group, Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento Microbiologia e Parasitologia. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento Microbiologia e Parasitologia. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.
Fleury Group, Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento Microbiologia e Parasitologia. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Faculdade de Farmácia. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Instituto Biomédico. Departamento Microbiologia e Parasitologia. Niterói, RJ, Brasil.
Resumo em Inglês
Background: Streptococcus agalactiae is known to be the major cause of neonatal infections and also causes complications
during pregnancy. Methods: One hundred and six strains of Streptococcus agalactiae recovered from clinical specimens of
newborns ( n 18) and pregnant women ( n 88) were submitted to antimicrobial susceptibility testing and investigation
of genetic determinants of macrolide resistance, capsular type, and virulence factors. Genetic diversity was evaluated by
pulsed-fi eld gel electrophoresis (PFGE) analysis. Results: Strains were susceptible to ceftriaxone, levofl oxacin, penicillin G,
and vancomycin and resistant to tetracycline (85.8%) and erythromycin (4.7%). Erythromycin-resistant strains presented
iMLS B phenotype, harbored the ermA gene, and were closely related by PFGE. Both bac and bca genes were found in
low frequencies. PFGE analysis yielded 11 DNA restriction profi les among 35 selected isolates. The major clonal group,
designated as A, was composed predominantly of strains belonging to capsular type Ia. Clonal group B was composed
predominantly of strains with capsular type V, including all erythromycin-resistant isolates. Conclusions: Although low levels
of erythromycin resistance have been observed, this is a fact of concern because this phenotype also confers resistance to
clindamycin, an alternative agent for intrapartum prophylaxis. Despite the diversity of capsular types, Ia and V were among
the most common and were signifi cantly associated with distinct clonal groups. In a few cases, different capsular types were
clustered into a single clonal group, which may be related to capsular switching.
Palavras-chave em inglês
Streptococcus AgalactiaeAntimicrobial Resistance
Genetic Diversity
Virulence Factors
Capsular Typing
DeCS
Streptococcus agalactiaeAnti-Infecciosos - análise
Variação Genética
Fatores de Virulência - análise
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