Author | Cunha, Liliane Monteiro | |
Author | Bittencourt, Paulo Lisboa | |
Author | Lemos, Clarice P. Abrantes | |
Author | Moreira, Agnaluce | |
Author | Almeida, Delvone | |
Author | Paraná, Raymundo | |
Author | Andrade, Zilton de Araújo | |
Access date | 2014-02-07T16:38:43Z | |
Available date | 2014-02-07T16:38:43Z | |
Document date | 2012 | |
Citation | CUNHA, L. M. et al. Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study. Human Immunology, v.73, n. 1, p. 70-74, 2012. | pt_BR |
ISSN | 1879-1166 | |
URI | https://www.arca.fiocruz.br/handle/icict/7297 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study | pt_BR |
Type | Article | pt_BR |
Abstract | Non-organ-specific autoantibodies (NOSA) are well-recognized diagnostic markers of autoimmune hepatitis
(AIH) and primary biliary cirrhosis (PBC), but can also be observed in patients with viral hepatitis as well as in
healthy subjects. The aim of this study was to evaluate the prevalence of NOSA in subjects living in a rural
community in Brazil and to correlate their occurrence with the presence of liver disease. Seven hundred
twenty-five apparently healthy subjects were randomly selected for assessment of antinuclear (ANA),
anti-smooth muscle (SMA), antimitochondrial (AMA), anti-liver/kidney microsome type 1, and anti-liver
cytosol type 1 antibodies. Subjects with those NOSA were evaluated for the presence of AIH, PBC, and viral
hepatitis. Reactivities for all NOSA, SMA, ANA, and AMA were detected, respectively, in 14, 10, 4, and 0.1% of
subjects, with a mean titer of 1:40. NOSA-positive subjects were significantly older and more frequently
females. No correlation was observed between the occurrence of NOSA and PBC, AIH, or viral hepatitis. The
prevalence of NOSA in Brazilians was 14%. They were usually low titer. NOSA were more frequently observed
in females and older subjects and their presence was not correlated with the presence of AIH, PBC, or viral
hepatitis | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Portuguese Hospital of Salvador. Salvador, BA, Brasil | pt_BR |
Affilliation | University of São Paulo School of Medicine. São Paulo, SP, Brasil | pt_BR |
Affilliation | LPC Laboratory. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Autoantibodies | pt_BR |
Subject | Rural population | pt_BR |
Subject | Autoimmunity | pt_BR |
Subject | Autoimmune diseases | pt_BR |
Subject | Liver diseases | pt_BR |
Subject | Cirrose Hepática Biliar/imunologia | pt_BR |
Subject | População Rural/estatística & dados numéricos | pt_BR |
Subject | Anticorpos Antinucleares/imunologia | pt_BR |
Subject | Adolescente | pt_BR |
Subject | Adulto | pt_BR |
Subject | Idoso | pt_BR |
Subject | Criança | pt_BR |
Subject | Feminino | pt_BR |
Subject | Técnica Indireta de Fluorescência para Anticorpo | pt_BR |
Subject | Hepatite Autoimune/diagnóstico | pt_BR |
Subject | Hepatite Viral Humana/diagnóstico | pt_BR |
Subject | Humanos | pt_BR |
Subject | Cirrose Hepática Biliar/diagnóstico | pt_BR |
Subject | Mitocôndrias/imunologia | pt_BR |
Subject | Músculo Liso/imunologia | pt_BR |
Subject | Prevalência | pt_BR |
Subject | Adulto jovem | pt_BR |
DeCS | Autoanticorpos/imunologia | pt_BR |
DeCS | Hepatite Autoimune/imunologia | pt_BR |
DeCS | Hepatite Viral Humana/imunologia | pt_BR |
xmlui.metadata.dc.subject.ods | 11 Cidades e comunidades sustentáveis | |