| Author | Frade, Amanda Farage | |
| Author | Oliveira, Lea Campos de | |
| Author | Costa, Dorcas Lamounier | |
| Author | Costa, Carlos Henrique Nery | |
| Author | Aquino, Dorlene Maria Cardoso de | |
| Author | Van Weyenbergh, Johan Jozef Rosa Maria | |
| Author | Barral Netto, Manoel | |
| Author | Barral, Aldina Maria Prado | |
| Author | Kalil, Jorge | |
| Author | Goldberg, Anna Carla | |
| Access date | 2014-02-26T17:26:57Z | |
| Available date | 2014-02-26T17:26:57Z | |
| Document date | 2011 | |
| Citation | FRADE, A. F. et al. TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis. Infection, Genetics and Evolution, v. 11, p. 912–916, 2011. | pt_BR |
| ISSN | 1567-7257 | |
| URI | https://www.arca.fiocruz.br/handle/icict/7356 | |
| Language | eng | pt_BR |
| Publisher | Elsevier B.V | pt_BR |
| Rights | open access | pt_BR |
| Title | TGFB1 and IL8 gene polymorphisms and susceptibility to visceral leishmaniasis | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1016/j.meegid.2011.02.014 | |
| Abstract | Visceral leishmaniasis (VL) or Kala-azar is a serious protozoan infectious disease caused by an obligate intracellular parasite. Cytokines have a major role in determining progression and severity of clinical manifestations in VL. We investigated polymorphisms in the TGFB1and IL8 genes, which are cytokines known to have a role in onset and severity of the disease. Polymorphisms at TGFB1 -509 C/T and +869 T/C, and IL8 -251 A/T were analyzed by a PCR-RFLP technique, in 198 patients with VL, 98 individuals with asymptomatic infection positive for a delayed-type hypersensitivity test (DTH+) and in 101 individuals with no evidence of infection (DTH-). The presence of the T allele in position -509 of the TGFB1 gene conferred a two-fold risk to develop infection both when including those with clinical symptoms (DTH+ and VL, grouped) or when considering DTH+ only, respectively p = 0.007, OR = 1.9 [1.19-3.02] and p = 0.012, OR = 2.01 [1.17-3.79], when compared with DTH- individuals. In addition, occurrence of hemorrhage was associated with TGFB1 -509 T allele. We suggest that the -509 T allele of the TGFB1 gene, a cytokine with a biologically relevant role in the natural history of the disease, may contribute to overall susceptibility to infection by Leishmania and to severity of the clinical disease. | pt_BR |
| Affilliation | Heart Institute (InCor) HC- FMUSP. Laboratory of Immunology. São Paulo, SP, Brasil | pt_BR |
| Affilliation | University of São Paulo. Central Institute. General Hospital. School of Medicine. Laboratory of Medicine Laboratorial. São Paulo, SP, Brasil | pt_BR |
| Affilliation | University Federal of Piauí. Teresina, PI, Brasil | pt_BR |
| Affilliation | University Federal of Piauí. Teresina, PI, Brasil | pt_BR |
| Affilliation | University Federal of Maranhão. São Luís, MA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute for Investigation in Immunology (iii)–INCT-CNPq – Brasil. Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Institute for Investigation in Immunology (iii)–INCT-CNPq – Brasil. Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Albert Einstein Institute for Education and Research. São Paulo, SP, Brasil / Institute for Investigation in Immunology (iii)–INCT-CNPq – Brasil. Brasil | pt_BR |
| Affilliation | Heart Institute (InCor) HC- FMUSP. Laboratory of Immunology. São Paulo, SP, Brasil / Institute for Investigation in Immunology (iii) – INCT-CNPq – Brasil. Brasil | pt_BR |
| Affilliation | Albert Einstein Institute for Education and Research. São Paulo, SP, Brasil / Institute for Investigation in Immunology (iii) – INCT-CNPq – Brasil. Brasil | pt_BR |
| Subject | Visceral leishmaniasis | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Gene polymorphisms | pt_BR |
| Subject | Disease susceptibility | pt_BR |
| DeCS | Predisposição Genética para Doença | pt_BR |
| DeCS | Interleucina-8/genética | pt_BR |
| DeCS | Leishmaniose Visceral/genética | pt_BR |
| DeCS | Fator de Crescimento Transformador beta1/genética | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Idoso | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Alelos | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Pré-Escolar | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Genótipo | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Lactente | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Meia-Idade | pt_BR |
