Author | Noronha, Almério Libório Lopes de | |
Author | Bafica, Andre Luiz Barbosa | |
Author | Nogueira, Lucas L | |
Author | Barral, Aldina Maria Prado | |
Author | Barral Netto, Manoel | |
Access date | 2014-03-13T14:01:44Z | |
Available date | 2014-03-13T14:01:44Z | |
Document date | 2008 | |
Citation | NORONHA, A. L. L. de Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. Pathology, Research and Practice, v. 204, p. 155–161, 2008. | pt_BR |
ISSN | 0344-0338 | |
ISSN | 10.1016/j.prp.2007.10.008 | |
URI | https://www.arca.fiocruz.br/handle/icict/7402 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. | pt_BR |
Type | Article | pt_BR |
Abstract | Tuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and previous studies have reported that co-infected individuals display major morphological alterations in tissue granulomas. The purpose of this study was to evaluate immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate with typical epithelioid, as well as giant cells, and exhibiting caseous necrosis. In contrast, lesions from the TB/HIV-1-co-infected group showed extensive necrosis, poorly formed granulomas, and a marked presence of polymorphonuclear cells. More importantly, TNF staining was greatly reduced in the TB/HIV-1-co-infected individuals. Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Santa Catarina. Division of Immunology, Microbiology and Parasitology Departament. Florianópolis, SC, BRasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Subject | Mycobacterium tuberculosis | pt_BR |
Subject | Autopsy | pt_BR |
Subject | Granuloma | pt_BR |
Subject | HIV | pt_BR |
Subject | TNF | pt_BR |
DeCS | Granuloma do Sistema Respiratório/imunologia | pt_BR |
DeCS | Infecções por HIV/complicações | pt_BR |
DeCS | Pulmão/imunologia | pt_BR |
DeCS | Tuberculose Pulmonar/complicações | pt_BR |
DeCS | Fator de Necrose Tumoral alfa/biossíntese | pt_BR |
DeCS | Infecções Oportunistas Relacionadas com a AIDS/imunologia | pt_BR |
DeCS | Infecções Oportunistas Relacionadas com a AIDS/patologia | pt_BR |
DeCS | Granuloma do Sistema Respiratório/microbiologia | pt_BR |
DeCS | Granuloma do Sistema Respiratório/patologia | pt_BR |
DeCS | Infecções Oportunistas Relacionadas com a AIDS/imunologia | pt_BR |
DeCS | Infecções por HIV/patologia | pt_BR |
DeCS | HIV-I | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Pulmão/microbiologia | pt_BR |
DeCS | Pulmão/patologia | pt_BR |
DeCS | Mycobacterium tuberculosis | pt_BR |
DeCS | Tuberculose Pulmonar/imunologia | pt_BR |
DeCS | Tuberculose Pulmonar/patologia | pt_BR |