Author | Costa, Ronaldo P | |
Author | Gollob, Kenneth J | |
Author | Machado, Paulo Roberto | |
Author | Bacellar, Maria Olívia Amado Ramos | |
Author | Almeida, Roque Pacheco de | |
Author | Barral, Aldina Maria Prado | |
Author | Barral Netto, Manoel | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Dutra, Walderez Ornelas | |
Access date | 2014-03-21T18:59:46Z | |
Available date | 2014-03-21T18:59:46Z | |
Document date | 2003 | |
Citation | COSTA, R. P. et al. Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients. Immunology Letters, v. 90, p. 155–159, 2003. | pt_BR |
ISSN | 0165-2478 | |
ISSN | 10.1016/j.imlet.2003.09.001 | |
URI | https://www.arca.fiocruz.br/handle/icict/7436 | |
Language | eng | pt_BR |
Publisher | Elsevier B.V | pt_BR |
Rights | open access | pt_BR |
Title | Adhesion molecule expression patterns indicate activation and recruitment of CD4+ T cells from the lymph node to the peripheral blood of early cutaneous leishmaniasis patients | pt_BR |
Type | Article | pt_BR |
Abstract | Adhesion molecules play a crucial role in cell migration and recruitment. Expression of adhesion molecules that preferentially address cells
to inflammatory sites is a critical event in the formation and maintenance of leishmaniasis lesions. In this work, we analyzed the expression
of CD11a, CD11b and CD62L, adhesion molecules involved in cell activation and circulation, in CD4+ and CD8+ T cells from peripheral
blood and lymph nodes of patients with early cutaneous leishmaniasis. The percentage of expression of CD62L, CD11a and CD11b in total
lymphocytes was lower in lymph nodes as compared to peripheral blood. Moreover, differences in adhesion molecule expression between
blood and lymph nodes were more striking in CD4+ than CD8+ T cells. Stimulation of PBMC from leishmaniasis patients with soluble
Leishmania antigens (SLA) lead to the expansion of CD4+CD62Lhigh cells, CD4+CD11b+ cells and to an increase in the intensity of
expression of CD11a in CD4+, but not CD8+ T cells. Our data suggest that early activation events that occur in the lymph nodes of patients
recently infected with Leishmania lead to changes in T cell adhesion molecule expression, favoring migration to the periphery and increasing
the likelihood of further recruitment to lesion sites. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gearis. ICB. Laboratory of Lymphocyte Biology. Department of Biochemistry-Immunolog. Belo Horizonte, Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. HUPES. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Laboratory of Cell–Cell Interactions. Department of Morphology. Biological Sciences Institute. Belo Horizonte, MG, Brasil | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | Adhesion molecules | pt_BR |
Subject | Lymph node | pt_BR |
Subject | Lymphocytes | pt_BR |
Subject | Peripheral blood | pt_BR |
DeCS | Linfócitos T CD4-Positivos/imunologia | pt_BR |
DeCS | Moléculas de Adesão Celular/metabolismo | pt_BR |
DeCS | Leishmaniose Cutânea/sangue | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Linfonodos/imunologia | pt_BR |
DeCS | Ativação Linfocitária | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Antígenos CD/análise | pt_BR |
DeCS | Antígenos CD/imunologia | pt_BR |
DeCS | Antígenos de Protozoários/imunologia | pt_BR |
DeCS | Linfócitos T CD8-Positivos/imunologia | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imunofenotipagem | pt_BR |
DeCS | Leishmania/imunologia | pt_BR |
DeCS | Linfonodos/citologia | pt_BR |