Author | Bandeira, Maurício | |
Author | Santos, Cleiton Silva | |
Author | Azevedo, Everton Cruz de | |
Author | Soares, Luciane Marieta | |
Author | Macedo, Júlio Oliveira | |
Author | Marchi, Samyra | |
Author | Silva, Caroline Luane Rabelo da | |
Author | Chagas Júnior, Adenizar Delgado das | |
Author | McBride, Alan John Alexander | |
Author | McBride, Flávia Weykamp da Cruz | |
Author | Reis, Mitermayer Galvão dos | |
Author | Athanazio, Daniel Abensur | |
Access date | 2014-04-04T18:55:38Z | |
Available date | 2014-04-04T18:55:38Z | |
Document date | 2011 | |
Citation | BANDEIRA, M. et al. Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. Infection and Immunity, v. 79, n. 7, p. 2936–2940, 2011. | pt_BR |
ISSN | 1098-5522 | |
URI | https://www.arca.fiocruz.br/handle/icict/7497 | |
Language | eng | pt_BR |
Publisher | American Society for Microbiology | pt_BR |
Rights | open access | pt_BR |
Title | Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1128/IAI.05099-11 | |
Abstract | The aims of this study were to investigate the frequency of pulmonary hemorrhage (PH) in mice unable to
produce functional B and T lymphocytes and to explore the effect of an inducible nitric oxide synthase gene
(Inos) knockout (KO) on the frequency/severity of interstitial nephritis in vivo. We studied the outcome of
infection by the virulent Leptospira interrogans serovar Copenhageni strain Cop. The animals used were Inos
KO mice, recombination activating gene 1 (Rag1) KO mice, CB17 severe combined immunodeficiency (SCID)
mice, and the respective wild-type (WT) C57BL/6 and BALB/c controls. The Inos KO and WT mice survived
with no clinical symptoms of leptospirosis. The frequency and severity of nephritis was significantly lower in
the Inos KO mice. All of the Rag1 KO and SCID animals died of acute leptospirosis, whereas all of the WT mice
survived. PH was observed in 57 and 94% of Rag1 KO mice and in 83 and 100% of SCID mice, using inoculum
doses of 107 and 106 leptospires, respectively. There was no evidence of PH in the WT controls. In conclusion,
the loss of the Inos gene had a negligible effect on the outcome of leptospiral infection, although we observed
a reduced susceptibility for interstitial nephritis in this group. Of note, the absence of functional B- and T-cell
lymphocytes did not preclude the occurrence of PH. These data provide evidence that PH in leptospirosis may
not be related only to autoimmune mechanisms. | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Genes RAG-1 | pt_BR |
DeCS | Hemorragia/imunologia | pt_BR |
DeCS | Leptospira interrogans | pt_BR |
DeCS | Leptospirose/imunologia | pt_BR |
DeCS | Pneumopatias/imunologia | pt_BR |
DeCS | Nefrite Intersticial/imunologia | pt_BR |
DeCS | Óxido Nítrico Sintase Tipo II/genética | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Linfócitos B/imunologia | pt_BR |
DeCS | Leptospirose/microbiologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Camundongos Knockout | pt_BR |
DeCS | Óxido Nítrico Sintase Tipo II/metabolismo | pt_BR |
DeCS | Linfócitos T/imunologia | pt_BR |