Autor | Blanton, Ronald Edward | |
Autor | Blank, Walter A | |
Autor | Costa, Jackson Mauricio Lopes | |
Autor | Carmo, Theomira Mauadie de Azevedo | |
Autor | Reis, Eliana Almeida Gomes | |
Autor | Silva, Luciano Kalabric | |
Autor | Barbosa, Lúcio Macedo | |
Autor | Test, Matthew R. | |
Autor | Reis, Mitermayer Galvão dos | |
Data de acesso | 2014-04-07T12:45:07Z | |
Data de disponibilização | 2014-04-07T12:45:07Z | |
Data do publicação | 2011 | |
Citação | BLANTON, R. E. et al. Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil. International Journal of Parasitology, v. 41, n. 10, p. 1093-1099, 2011. | pt_BR |
ISSN | 1879-0135 | |
URI | https://www.arca.fiocruz.br/handle/icict/7499 | |
Idioma | eng | pt_BR |
Editor | National Institute of Health | pt_BR |
Direito Autoral | open access | pt_BR |
Título | Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil | pt_BR |
Tipo do documento | Article | pt_BR |
DOI | 10.1016/j.ijpara.2011.06.002. | |
Resumo em Inglês | Praziquantel has been used to treat schistosome infections since 1979 and currently is the only
chemotherapeutic agent in production for this purpose, raising concerns about the potential for the
emergence of drug resistance. In practice, 10–20% of infected patients will continue to excrete
eggs after treatment. It is not understood to what degree this represents selection of a resistant
population or incomplete elimination due to the presence of immature worms at the time of
treatment. We used a population genetics approach to test whether or not persistent Schistosoma
mansoni parasites were drawn from the same population as susceptible parasites. In this study,
stool samples were collected from 96% of individuals in two small Brazilian communities
(populations 482 and 367) and examined for S. mansoni eggs. The combined prevalence of S.
mansoni infections in the villages was 41%. Total egg DNA was extracted from each sample and
was genotyped at 15 microsatellite markers. Day-to-day variation of the infrapopulation from an
individual human host was low (median differentiation using Jost’s D = 0.010), so that a single
stool was representative of the genotypes present in stool eggs, at least in the short term. Average
pairwise analysis of D among all pre-treatment infrapopulations suggested moderate
differentiation (mean D = 0.082 and 0.122 for the two villages), whereas the pre-treatment
component population differentiation between the two communities was 0.047. The differentiation
of the component population remaining after treatment from the fully susceptible component
population was low (mean D = 0.007 and 0.020 for the two villages), suggesting that the persistent
parasites were not selected by praziquantel treatment. We will continue to follow these
communities for evidence of selection or changes in population structure. | pt_BR |
Afiliação | Case Western Reserve University. Centre for Global Health and Diseases. Cleveland, OH, USA | pt_BR |
Afiliação | Case Western Reserve University. Centre for Global Health and Diseases. Cleveland, OH, USA | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Afiliação | Case Western Reserve University. Centre for Global Health and Diseases. Cleveland, OH, USA | pt_BR |
Afiliação | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Palavras-chave em inglês | Praziquantel | pt_BR |
Palavras-chave em inglês | Resistance | pt_BR |
Palavras-chave em inglês | Microsatellite | pt_BR |
Palavras-chave em inglês | Population genetics | pt_BR |
Palavras-chave em inglês | Sampling | pt_BR |
Palavras-chave em inglês | Genetic differentiation | pt_BR |
Palavras-chave em inglês | Selection | pt_BR |
DeCS | Anti-Helmínticos/administração & dosagem | pt_BR |
DeCS | Resistência a Medicamentos | pt_BR |
DeCS | Praziquantel/administração & dosagem | pt_BR |
DeCS | Schistosoma mansoni/classificação | pt_BR |
DeCS | Schistosoma mansoni/efeitos de drogas | pt_BR |
DeCS | Esquistossomose mansoni/quimioterapia | pt_BR |
DeCS | Seleção Genética | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Idoso de 80 anos ou mais | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Fezes/parasitologia | pt_BR |
DeCS | Pré-Escolar | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Repetições de Microssatélites | pt_BR |
DeCS | Lactente | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Schistosoma mansoni/genética | pt_BR |
DeCS | Adulto-Jovem | pt_BR |