Author | Santos, Cleiton Silva | |
Author | Macedo, Júlio Oliveira | |
Author | Bandeira, Maurício | |
Author | Chagas Júnior, Adenizar Delgado das | |
Author | McBride, Alan John Alexander | |
Author | McBride, Flávia Weykamp da Cruz | |
Author | Reis, Mitermayer Galvão dos | |
Author | Athanazio, Daniel Abensur | |
Access date | 2014-04-08T14:04:49Z | |
Available date | 2014-04-08T14:04:49Z | |
Document date | 2010 | |
Citation | SANTOS, C. S. et al. Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes. Journal of Medical Microbiology, v. 59, n. 9, p. 1101–1106, 2010. | pt_BR |
ISSN | 1473-5644 | |
ISSN | 10.1099/jmm.0.021089-0 | |
URI | https://www.arca.fiocruz.br/handle/icict/7503 | |
Language | eng | pt_BR |
Publisher | SGM | pt_BR |
Rights | open access | pt_BR |
Title | Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes. | pt_BR |
Type | Article | pt_BR |
Abstract | The mouse disease model has the advantage of a broad array of immunological and genetic tools
available for basic research. Some studies on transgenic and/or mutant mouse strains as models
for experimental leptospirosis have been reported; however, the wider use of such models is
hampered by a poor understanding of the outcome of experimental leptospiral infection among the
different mouse strains available. Here, the outcome of infection by a virulent strain of Leptospira
interrogans serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wildtype
mouse strains: A, CBA, BALB/c and C57BL/6. The end points evaluated in this study were
survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination
test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were
susceptible to lethal leptospirosis. However, these strains developed specific pathologies
associated with sublethal leptospirosis. The A and C57BL/6 strains exhibited a high leptospiral
load in kidney samples and the CBA and C57BL/6 strains developed severe inflammatory lesions,
whilst the BALB/c strain proved to be the most resistant to subclinical leptospirosis | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Salvador, BA, Brasil | pt_BR |
DeCS | Predisposição Genética para Doença | pt_BR |
DeCS | Genótipo | pt_BR |
DeCS | Leptospirose/genética | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Leptospira interrogans | pt_BR |
DeCS | Leptospirose/imunologia | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos | pt_BR |