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https://www.arca.fiocruz.br/handle/icict/7575
SCHISTOSOMA MANSONI INFECTION AND NUTRITIONAL STATUS IN SCHOOLCHILDREN: A RANDOMIZED, DOUBLE-BLIND TRIAL IN NORTHEASTERN BRAZIL
Growth
Sex
Oxamniquine
Morbidity
Therapy
Anthropometry
Parasitic infection
Schoolchildren
Oxamniquine/uso terapêutico
Esquistossomose mansoni/quimioterapia
Esquistossomicidas/uso terapêutico
Adolescente
Antropometria
Índice de Massa Corporal
Peso Corporal
Brasil
Criança
Método Duplo-Cego
Feminino
Humanos
Masculino
Placebos
Esquistossomose mansoni/fisiopatologia
Pregas Cutâneas
Author
Affilliation
Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Department of Nutrition and Division of Geographic Medicine. Case Western Reserve University School of Medicine. Cleveland
Department of Nutrition and Division of Geographic Medicine. Case Western Reserve University School of Medicine. Cleveland
Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Federal University of Bahia. Department of Nutrition Sciences and Institute of Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Department of Nutrition and Division of Geographic Medicine. Case Western Reserve University School of Medicine. Cleveland
Department of Nutrition and Division of Geographic Medicine. Case Western Reserve University School of Medicine. Cleveland
Abstract
Brazilian schoolchildren with mild- to moderate-intensity schistosome infections (<400 Schistosoma mansoni eggs/g stool) were randomly allocated to a treatment (oxamniquine) or placebo group in a double-blind fashion. Anthropometric measurements were made at baseline, 6 mo, and 1 y for 353 students. At baseline, the groups were not significantly different with respect to nutritional status or selected socioeconomic and biological characteristics, including anthropometric measures. One year later, significant differences were noted only in the nutritional status of boys treated for schistosome infection. Treated boys had greater measurements for weight, triceps skinfold thickness, midarm circumference, arm muscle area, and body mass index than untreated boys. They also showed significant increases over the year in weight, height, midarm circumference, and body mass index. The rates of improvement in weight and height were more accelerated in the first 6 mo after therapy than the last. These results indicate that, at least in boys, chronic S. mansoni infection at any intensity is detrimental to short-term growth and development.
Keywords
Schistosoma mansoniGrowth
Sex
Oxamniquine
Morbidity
Therapy
Anthropometry
Parasitic infection
Schoolchildren
DeCS
Estado NutricionalOxamniquine/uso terapêutico
Esquistossomose mansoni/quimioterapia
Esquistossomicidas/uso terapêutico
Adolescente
Antropometria
Índice de Massa Corporal
Peso Corporal
Brasil
Criança
Método Duplo-Cego
Feminino
Humanos
Masculino
Placebos
Esquistossomose mansoni/fisiopatologia
Pregas Cutâneas
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