Author | Miranda, Aline Cristina Andrade Mota | |
Author | Barreto, Fernanda Khouri | |
Author | Baptista, Everton | |
Author | Vale, Lourdes Farre | |
Author | Cunha, Joana Paixão Monteiro | |
Author | Castro Filho, Bernardo Galvão | |
Author | Alcantara, Luiz Carlos Júnior | |
Access date | 2014-06-04T12:54:34Z | |
Available date | 2014-06-04T12:54:34Z | |
Document date | 2013 | |
Citation | MOTA-MIRANDA, A.C. A. et al. Molecular study of HBZ and gp21 human T cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals. AIDS Research and Human Retroviruses, v. 29, n. 10, p. 1370-1372, 2013. | pt_BR |
ISSN | 1931-8405 | |
URI | https://www.arca.fiocruz.br/handle/icict/7789 | |
Language | eng | pt_BR |
Publisher | Mary Ann Liebert, Inc | pt_BR |
Rights | open access | pt_BR |
Title | Molecular study of HBZ and gp21 human T cell leukemia virus type 1 proteins isolated from different clinical profile infected individuals. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1089/aid.2013.0015 | |
Abstract | Human T cell leukemia virus type 1 (HTLV-1) is associated with a neurological syndrome named tropical spastic
paraparesis/HTLV-associated myelopathy (TSP/HAM) and the disease progression involves viral factors. The
gp21 glycoprotein is involved in envelope trafficking and membrane targeting while the bZIP protein is indispensable
for cell growth and proliferation. This study aimed to assess the molecular diversity of gp21 and
HBZ proteins in TSP/HAM and healthy carriers. DNA samples from HTLV-1-infected individuals were submitted
to PCR and sequencing, and the molecular analyses were performed using bioinformatics tools. From
eight gp21-analyzed sequences one amino acid change (Y477H) was associated with the switch of a helix to coil
structure at secondary structure prediction. From 10 HBZ analyzed sequences, two amino acid changes were
identified (S9P and T95I) at the activation domain. One mutation (R112C) located at the nuclear localization
signal was present in 66.7% and 25% of healthy carriers (HC) and TSP/HAM groups, respectively. This is the
first report of mutations in the HBZ region. These polymorphisms might be important for viral fitness. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil /Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil /Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Fatores de Transcrição de Zíper de Leucina Básica/genética | pt_BR |
DeCS | Variação Genética | pt_BR |
DeCS | Infecções por HTLV-I/virologia | pt_BR |
DeCS | Vírus 1 Linfotrópico T Humano/genética | pt_BR |
DeCS | Proteínas Virais/genética | pt_BR |
DeCS | Produtos do Gene env do Vírus da Imunodeficiência Humana/genética | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Vírus 1 Linfotrópico T Humano/isolamento & purificação | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Dados de Sequência Molecular | pt_BR |
DeCS | Proteínas Mutantes/genética | pt_BR |
DeCS | Mutação Puntual | pt_BR |
DeCS | RNA Viral/genética | pt_BR |
DeCS | Análise de Sequência de DNA | pt_BR |