Author | Cotrim, Helma Pinchemel | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Alves, Erivaldo | |
Author | Almeida, Alessandro de Moura | |
Author | May, Daniel Simões | |
Author | Caldwell, Stephen H. | |
Access date | 2014-06-11T16:42:30Z | |
Available date | 2014-06-11T16:42:30Z | |
Document date | 2009 | |
Citation | COTRIM, H. P. et al. Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients. European Journal of Gastroenterology & Hepatology, v. 21, n. 9, p. 969-972, 2009. | pt_BR |
ISSN | 1473-5687 | |
ISSN | 10.1097/MEG.0b013e328328f3ec | |
URI | https://www.arca.fiocruz.br/handle/icict/7812 | |
Language | eng | pt_BR |
Publisher | Lippincott Williams & Wilkins | pt_BR |
Rights | open access | pt_BR |
Title | Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients. | pt_BR |
Type | Article | pt_BR |
Abstract | OBJECTIVES: The effect of light-to-moderate alcohol consumption (LMAC) in nonalcoholic fatty liver disease (NAFLD) remains a controversial subject. The aim of this study was to evaluate the relationship between LMAC and the severity of NAFLD in morbidly obese patients. METHODS: We studied 132 patients undergoing liver biopsy during bariatric surgery. The patients were divided into three groups: G1: alcohol intake greater than 20 g/day and less than 40 g/day; G2: alcohol intake less than 20 g/day; G3: no alcohol intake. Insulin resistance was defined by the Homeostasis Model Assessment (>3). NAFLD was classified according to the Matteoni types: type I: steatosis alone; type II: steatosis with inflammation; types III-IV: steatosis with ballooning and/or fibrosis. RESULTS: The mean age was 37.3+/-11 years. Sixty-three percent were females and body mass index was 43.9+/-5.6 kg/m. G1, G2, and G3 included 19, 56, and 57 patients, respectively. Histological diagnoses classified by levels of alcohol were: G1: 10.5% normal liver, 89.5% type III or IV; G2: 10.7% normal liver, 1.8% type I or II, and 87.5% grade III or IV; G3: 10.5% normal liver, 3.5% type I or II, and 86% type III or IV (one had cirrhosis). The presence of IR was similar in moderate and no alcohol consumption (81.3 and 78.7%) but significantly less in the light consumption group (54%, P<0.05). CONCLUSION: The results suggest that LMAC may have a protection effect against IR in severely obese patients. However, it had no impact on the severity of activity and stage of liver disease. | pt_BR |
Affilliation | Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Center for the Surgical Treatment of Obesity. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Postgraduate Course in Medicine and Health (PPGMS). Salvador, BA, Brasil | pt_BR |
Affilliation | Division of GI/Hepatology. University of Virginia. Charlottesville, USA | pt_BR |
Subject | Alcoholic liver disease | pt_BR |
Subject | Insulin resistance | pt_BR |
Subject | Nonalcoholic fatty liver disease | pt_BR |
Subject | Obesity | pt_BR |
DeCS | Consumo de Bebidas Alcoólicas/efeitos adversos | pt_BR |
DeCS | Fígado Gorduroso/patologia | pt_BR |
DeCS | Obesidade Mórbida/complicações | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Cirurgia Bariátrica | pt_BR |
DeCS | Índice de Massa Corporal | pt_BR |
DeCS | Estudos Transversais | pt_BR |
DeCS | Fígado Gorduroso/quimioterapia | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Resistência à Insulina/fisiologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Obesidade Mórbida/quimioterapia | pt_BR |
DeCS | Adulto Jovem | pt_BR |